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Morphogenesis of Aragonite Biomineral Structures by the Nonclassical Colloidal Crystal Growth Mechanism Revisited on the Nanoscale: The Noah's Ark Shell (, L.) Case Study.
ACS Biomater Sci Eng
January 2025
Advanced Materials Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.
Characterization and formation of the biomineral aragonite structures of the Noah's Ark shell ( L.,1758) were studied from structural, morphogenetic, and biochemical points of view. Structural and morphological features were examined using X-ray diffraction, field-emission scanning electron microscopy, and atomic force microscopy, while thermal properties were determined by thermogravimetric and differential thermal analyses.
View Article and Find Full Text PDFProvision of Radiology Reports Simplified With Large Language Models to Patients With Cancer: Impact on Patient Satisfaction.
JCO Clin Cancer Inform
January 2025
Department of Radiology, Dr BRAIRCH, All India Institute of Medical Sciences, New Delhi, India.
Purpose: To explore the perceived utility and effect of simplified radiology reports on oncology patients' knowledge and feasibility of large language models (LLMs) to generate such reports.
Materials And Methods: This study was approved by the Institute Ethics Committee. In phase I, five state-of-the-art LLMs (Generative Pre-Trained Transformer-4o [GPT-4o], Google Gemini, Claude Opus, Llama-3.
Tooth replacement of the filter-feeding pterosaur Forfexopterus and its implications for ecological adaptation.
An Acad Bras Cienc
January 2025
Shandong University of Science and Technology, College of Earth Science and Engineering, 579, Qianwangang Road, Huangdao, Qingdao, Shandong Province, 266590, China.
A "comb-dentition", characterized by long, needle-like, and closely-spaced teeth, is found in the ctenochasmatid pterosaurs as an adaptation for filter-feeding. However, little is known about their tooth replacement pattern, hindering our understanding of the development of the filter-feeding apparatus of the clade. Here, we describe the tooth replacement of the pterosaur Forfexopterus from the Jehol Biota based on high-resolution X-ray Computed Tomography (CT) reconstruction.
View Article and Find Full Text PDFN-Heterocyclic Carbene Deposition on a Copper Powder Surface Using Mechanochemistry.
ACS Appl Mater Interfaces
January 2025
Department of Chemistry, McGill University, Montréal, Québec H3A 0G4, Canada.
Metal powders are crucial precursors for manufacturing surfaces through thermal spraying, cold spraying, and 3D printing methods. However, surface oxidation of these precursors poses a challenge to the coherence of the metallic materials during manufacturing processes. Herein, we introduce a method for surface modification of copper powder with N-heterocyclic carbenes (NHCs) using mechanochemistry to mitigate surface oxidation.
View Article and Find Full Text PDFRole of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding.
ACS Infect Dis
January 2025
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising antibiotic target. This enzyme catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), which is the rate-limiting step in guanine nucleotide biosynthesis. Bacterial IMPDH-specific inhibitors have been developed that bind to the NAD site.
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