AI Article Synopsis
- The study examined the link between IRAK1 and MECP2 genes and autoimmune thyroid diseases (AITDs) by analyzing four specific single nucleotide polymorphisms (SNPs) in a large group of patients and controls.
- The results showed that certain minor alleles of the SNPs were significantly associated with AITDs, particularly in cases of Graves' disease and Hashimoto's thyroiditis, with notable differences in female patients.
- The findings suggest that IRAK1 and MECP2 genes play an important role as risk factors in the development of AITDs.
Article Abstract
Our objective was to investigate whether interleukin-1 receptor-associated kinase (IRAK1) and methyl-CpG-binding protein 2 (MECP2) are associated with autoimmune thyroid diseases (AITDs). We selected four single nucleotide polymorphisms (SNPs), rs3027898, rs1059703 in IRAK1 and rs2075596, rs2239464 in MECP2, for genotyping using PCR-based ligase detection reaction (LDR) method in 1042 AITDs patients and 897 controls. Minor alleles in the four SNPs were strongly associated with AITDs, and similar associations were found in Graves' disease (GD). In Hashimoto's thyroiditis (HT) patients, a significantly increased risk of T allele in rs1059703 was found. There were obvious differences in allele and genotype distributions in female AITDs, GD and HT patients. Moreover, the haplotypes CCAA and ATGG were the associated variants for AITDs and GD. Besides, these two haplotypes showed similar associations with AITDs and GD in female patients. Our results firstly indicated that IRAK1 and MECP2 genes are crucial risk factors for AITDs.
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| http://dx.doi.org/10.1016/j.mce.2014.10.013 | DOI Listing |
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