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The relationship between connective tissue disease and autoantibody positivity in pneumoconiosis cases.
Medicine (Baltimore)
March 2025
Occupational Diseases Clinic, Eskişehir City Hospital, Eskişehir, Turkey.
This correlation has been studied since the 1930s, and it is believed that exposure to silica can lead to various autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. The exact mechanisms behind this link remain unclear. This study aimed to evaluate the prevalence of connective tissue diseases (CTD) and positive autoantibodies in pneumoconiosis patients and the association between radiological categorization and autoantibodies.
View Article and Find Full Text PDFEffect of Salivary Flow Rate, Particle Size, and Concentration on Sensations and Liking for Fiber-Fortified Beverages.
J Texture Stud
April 2025
Sensory Evaluation Center, The Pennsylvania State University, University Park, Pennsylvania, USA.
Xerostomia (perceived oral dryness) is a common problem in older adults, often due to hyposalivation, which can cause difficulty in eating and swallowing, resulting in insufficient dietary fiber intake. Recent work shows salivary flow rate, particle size, and concentration are major factors for particle perception in beverages. Given that disliking drives non-consumption, here we explore how particle size, concentration, and salivary flow rate may affect liking in a fiber-fortified model beverage.
View Article and Find Full Text PDFAntifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner.
J Oral Biol Craniofac Res
February 2025
Department of Prosthodontics, Thai Moogambigai Dental College, Dr. M.G.R. Educational and Research Institute, Chennai, India.
Introduction: The rough surface of dentures, coupled with xerostomia and immunosuppression, fosters microbial growth and colonization, with being a primary culprit. Tissue conditioners, used to reline ill-fitting dentures, can temporarily alleviate discomfort but are prone to microbial colonization. To address this, researchers have explored incorporating antifungal agents directly into tissue conditioners.
View Article and Find Full Text PDF'iCycle-pBAO': Automated patient-specific beam-angle selection in proton therapy applied to oropharyngeal cancer.
Radiother Oncol
February 2025
Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam University Medical Center, Rotterdam, the Netherlands.
Objective: This study aimed to develop a fully-automated patient tailored beam-angle optimisation approach for intensity-modulated proton therapy (IMPT). For oropharynx cancer patients, the dosimetric impact of increasing the number of fields from 4 to 12 was systematically assessed.
Approach: A total-beam-space heuristic was developed to simultaneously select optimal patient specific candidate beam directions, according to a cost-function that penalises dose to OARs involved in clinically used NTCPs.
Evaluation of a comprehensive set of normal tissue complication probability models for patients with head and neck cancer in an international cohort.
Oral Oncol
March 2025
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:
Background/purpose: Normal tissue complication probability (NTCP) models can be used to guide radiation therapy (RT) decisions by estimating side-effect risks pretreatment to minimize (late) side-effects. Recently, a comprehensive individual toxicity risk (CITOR) profile of NTCP models addressing common side-effects in head and neck cancer (HNC) patients was developed. This study investigates the generalizability of these models in an international setting, with different treatment approaches and side-effect assessments, promoting their integration into more widespread clinical practice.
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