Parkinson's disease is a neurodegenerative disorder that involves the degeneration of nigrostriatal dopaminergic neurons. Elevated levels of reactive oxygen species have been shown to deplete cellular levels of the ubiquitous antioxidant glutathione, leading to oxidative stress and eventual neuronal cell death. Dithiolethiones, a class of sulfur-containing heterocyclic molecules, have been shown to induce cellular production of glutathione in a variety of tissues, but have not been extensively evaluated in neurons. Herein, we report the synthesis and preliminary structure-activity relationships study of several substituted dithiolethiones. Three molecules were identified (D3T, CPDT, and 2d) that potently induced cellular glutathione in the SH-SY5Y neuroblastoma cell line. Furthermore, these compounds were found to provide neuroprotection in the 6-hydroxydopamine model of neurotoxicity. This study suggests that dithiolethione-mediated neuroprotection may have potential as a disease-modifying antiparkinsonian therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2014.10.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dissecting Key Factors Influencing Electrochemical Conversion of Carbon Solutions over Nickel Single Atoms.
Small
January 2025
Environment Research Institute, Shandong University, Qingdao, 266237, China.
The direct electrochemical conversion of bicarbonate solutions (i.e., captured CO) has emerged as a sustainable approach for integrating CO capture and utilization compared to the traditional independent and sequential route.
View Article and Find Full Text PDFCoordination Self-Assembly Induced Hot Exciton Fluorescence and Multi-Source Excitation Long Afterglow.
Angew Chem Int Ed Engl
January 2025
Sun Yat-Sen University, School of Chemistry and Chemical Engineering, 135 West Xingang Road, 510275, Guangzhou, CHINA.
Metal-organic complexes with long afterglow luminescence have attracted extensive attention due to potential applications in display, sensing and information security. However, most of the metal-organic complex long afterglow materials reported so far are limited to the use of UV light as the excitation source, and the ambiguity of the structure-activity relationship makes the development of metal-organic complexes extremely limited. Herein, a series of metal-organic complexes with ultralong emission lifetime is constructed by coordination assembly of Zn(II) with three isomers.
View Article and Find Full Text PDFNanomaterials-Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine.
Small Methods
January 2025
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing, 100190, China.
Pyroptosis, a form of programmed cell death characterized by cell lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel and intelligent therapeutic strategies for cancer, infectious diseases, and chronic inflammatory conditions with targeted activation and reduced systemic toxicity. This review explores the mechanisms by which NMs regulate pyroptosis, comparing molecular and NM inducers, and examines the role of intrinsic properties such as size, shape, surface charge, and chemical composition in these processes.
View Article and Find Full Text PDFStructure-Function Analysis of Volatile (Z)-3-Fatty Alcohols in Tomato.
J Chem Ecol
January 2025
Department of Biological Sciences, University of South Carolina, Columbia, SC, USA.
Plants emit green leaf volatiles (GLVs) in response to biotic and abiotic stress. Receiver plants perceive GLVs as alarm cues resulting in activation of defensive or protective mechanisms. While this is well documented, it is not known how GLVs are perceived by receiver cells and what the structural determinants are for GLV activity.
View Article and Find Full Text PDFAntimicrobial Activities of Polysaccharide-Rich Extracts from the Irish Seaweed , Generated Using Green and Conventional Extraction Technologies, Against Foodborne Pathogens.
Mar Drugs
January 2025
Section of Food and Nutrition, School of Agriculture and Food Science, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
A rise in antimicrobial resistance coupled with consumer preferences towards natural preservatives has resulted in increased research towards investigating antimicrobial compounds from natural sources such as macroalgae (seaweeds), which contain antioxidant, antimicrobial, and anticancer compounds. This study investigates the antimicrobial activity of compounds produced by the Irish seaweed against and , bacterial species which are relevant for food safety. Microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), ultrasound-microwave-assisted extraction (UMAE), and conventional extraction technologies (maceration) were applied to generate extracts from , followed by their preliminary chemical composition (total phenolic content, total protein content, total soluble sugars) and antimicrobial activity (with minimum inhibitory concentration determined by broth microdilution methods), examining also the molecular weight distribution (via high performance size exclusion chromatography) and oligosaccharide fraction composition (via high-performance liquid chromatography) of the polysaccharides, as they were the predominant compounds in these extracts, aiming to elucidate structure-function relationships.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!