Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 and SVA retrotransposons in humans, highlighting the evolutionary interplay between retroelements and their hosts.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892340 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2014.10.019 | DOI Listing |
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