AI Article Synopsis
- Dengue is the leading vector-borne viral disease globally, causing more human illness than any other similar disease, prompting research into better prediction and control methods.
- Recent advancements include improved epidemiology, understanding immune responses, and development of animal models, but significant challenges like limited surveillance and predicting severe cases persist.
- Future efforts should focus on creating effective vaccines and antiviral treatments to manage the growing burden of dengue as it spreads geographically.
Article Abstract
Dengue causes more human morbidity globally than any other vector-borne viral disease. Recent research has led to improved epidemiological methods that predict disease burden and factors involved in transmission, a better understanding of immune responses in infection, and enhanced animal models. In addition, a number of control measures, including preventative vaccines, are in clinical trials. However, significant gaps remain, including the need for better surveillance in large parts of the world, methods to predict which individuals will develop severe disease, and immunologic correlates of protection against dengue illness. During the next decade, dengue will likely expand its geographic reach and become an increasing burden on health resources in affected areas. Licensed vaccines and antiviral agents are needed in order to effectively control dengue and limit disease.
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| http://dx.doi.org/10.1016/j.jcv.2014.08.031 | DOI Listing |
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