The difficulties in investigation of the single neuron integrative properties in mammalian brain are connected with the absence of a mean of determination of neuronal set contribution in their activity. In given paper an experimental approach to the decision of this task is proposed. It consists in neuron activity investigation in the model learning training situation under condition of partial functional isolation from nervous cells by means of decrease in extracellular calcium concentration level using ethylene glycol tetraacetate. As indicator of such isolation was a partial or total reduction of responses in investigated neurons to electric microstimulation of neighbouring (200-240 mkm) parts of neocortex. The results of analysis of neuron responses in sensomotor cortex in the rat's brain in the process of acetylcholine repetitive local application give possibility to propose that some neurons don't exhibit plasticity according to the indicator in the dynamics of impulse discharge rate in responses to transmitter.
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