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Systematic bias in malaria parasite relatedness estimation.
G3 (Bethesda)
January 2025
Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Université Paris Cité, Paris 75015, France.
Genetic studies of Plasmodium parasites increasingly feature relatedness estimates. However, various aspects of malaria parasite relatedness estimation are not fully understood. For example, relatedness estimates based on whole-genome-sequence (WGS) data often exceed those based on sparser data types.
View Article and Find Full Text PDFAttention-aware differential learning for predicting peptide-MHC class I binding and T cell receptor recognition.
Brief Bioinform
November 2024
School of Computer Science, Northwestern Polytechnical University, Xi'an, 710129 Shaanxi, China.
The identification of neoantigens is crucial for advancing vaccines, diagnostics, and immunotherapies. Despite this importance, a fundamental question remains: how to model the presentation of neoantigens by major histocompatibility complex class I molecules and the recognition of the peptide-MHC-I (pMHC-I) complex by T cell receptors (TCRs). Accurate prediction of pMHC-I binding and TCR recognition remains a significant computational challenge in immunology due to intricate binding motifs and the long-tail distribution of known binding pairs in public databases.
View Article and Find Full Text PDFCorrection: Immune checkpoint inhibitors-related thyroid dysfunction: influencing factor analysis, prediction model development, and management strategy proposal.
Cancer Immunol Immunother
January 2025
Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China.
Exercising Self-Control Increases Responsivity to Hedonic and Eudaimonic Rewards.
Soc Cogn Affect Neurosci
January 2025
Centre for Research on Self and Identity, School of Psychology, University of Southampton, United Kingdom.
The reward responsivity hypothesis of self-control proposes that, irrespective of self-control success, exercising self-control is aversive and engenders negative affect. To countermand this discomfort, reward-seeking behavior may be amplified after bouts of self-control, bringing individuals back to a mildly positive baseline state. Previous studies indicated that effort-an integral component of self-control-can increase reward responsivity.
View Article and Find Full Text PDFArtificial intelligence, recessionary pressures and population health.
Bull World Health Organ
February 2025
Swiss Academies of Arts and Sciences, Bern, Switzerland.
Economic and labour policies have a considerable influence on health and well-being through direct financial impacts, and by shaping social and physical environments. Strong economies are important for public health investment and employment, yet the rapid rise of generative artificial intelligence (AI) has the potential to reshape economies, presenting challenges beyond mere temporary market disruption. Generative AI can perform non-routine cognitive tasks, previously unattainable though traditional automation, creating new efficiencies.
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