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Fibromyalgia is an idiopathic chronic widespread pain syndrome marked with specified tender points. There is no permanent cure of the disease. A 50-year-old man and his 49-year-old wife suffered from widespread pain, morning stiffness, sleep problems, and fatigue with complaints of brain fogging and forgetfulness from the past 13 and 26 years, respectively.

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Article Synopsis
  • The study aimed to see if a treatment called rTMS could help people with fibromyalgia sleep better.
  • It involved 42 patients who either got the real treatment or a fake one, going through 20 sessions.
  • Results showed that those who received the real rTMS treatment had much better sleep quality after 1 and 3 months compared to those who didn't.
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Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents.

Exp Brain Res

December 2024

Neuromodulation Center, Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Article Synopsis
  • Fibromyalgia syndrome (FMS) is a complex, chronic condition often marked by widespread pain and fatigue, primarily affecting women, leading to challenges in diagnosis and treatment.
  • This study investigated the link between transcranial magnetic stimulation (TMS) metrics—like cortical excitability and inhibition—and various clinical characteristics in 108 FMS patients, revealing associations between TMS markers, pain severity, fatigue, and medication use.
  • Findings suggest that disrupted brain inhibitory functions are linked to FMS symptoms, with factors like gabapentinoids and nicotine potentially impacting the brain's pain modulation mechanisms.
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Objectives: To summarise the available evidence and assess the effectiveness of medium and long-term physiotherapy treatment in adults with fibromyalgia (FM).

Methods: This systematic review was registered in PROSPERO: CRD42023388356. The databases searched were MEDLINE, PEDro, Scopus, Cinhal, LatinIndex, and Cochrane, using the following keywords: "fibromyalgia", "physiotherapy", "treatment", "therapeutic exercise", "TENS", "laser therapy" and "manual therapy.

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Fibromyalgia and osteoarthritis are among the most prevalent rheumatic conditions worldwide. Nonpharmacological interventions have gained scientific endorsements as the preferred initial treatments before resorting to pharmacological modalities. Repetitive transcranial magnetic stimulation (rTMS) is among the most widely researched neuromodulation techniques, though it has not yet been officially recommended for fibromyalgia.

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