AI Article Synopsis
- The study examines the effectiveness of different first-line platinum-based chemotherapy regimens for patients with advanced lung squamous cell carcinoma (SCC).* -
- Researchers analyzed data from the Taiwan Cancer Registry and determined that there was no significant difference in overall survival among different chemotherapy combinations used.* -
- The findings suggest that while certain regimens varied in prescription rates, none led to better survival outcomes, indicating that the specific chemotherapy regimen may not be a strong predictor of survival in this patient group.*
Article Abstract
Background: Platinum-based chemotherapy is the standard first-line therapy for patients with advanced lung squamous cell carcinoma (SCC). We compared the effectiveness of first-line chemotherapy regimens.
Methods: We searched the database of the Taiwan Cancer Registry for patients with newly diagnosed advanced lung SCC from 2004 to 2007. Medication prescription data were retrieved from the database of National Health Insurance, Taiwan. We identified patients who received standard first-line platinum-based chemotherapy, which was defined as chemotherapy with a platinum (P) compound (cisplatin or carboplatin) in addition to 1 of the 4 chemotherapy agents, including gemcitabine (G), docetaxel (D), paclitaxel (T), and vinorelbine (V). Deaths were identified by searching the National Death Registry. Overall survival (OS) was compared between patients who underwent different therapies.
Results: In total, 2790 patients were identified; 983 patients (35.2%) received standard first-line chemotherapy with P and G (58.1%), D (14.5%), T (11.6%), or V (15.8%). Older patients (age ≥ 70 years) were less likely to receive P + D than P + G, P + T, or P + V (P = .018). Patients who received P + G, P + D, P + T, or P + V had similar OS (median, 8.9, 7.9, 9.5, and 8.2 months; P = .816). In multivariate analyses adjusting for age, sex, and stage, the first-line chemotherapy regimen was not a predictor for OS. With P + G as the reference group, the adjusted hazard ratios of P + D, P + T, and P + V were 1.03, 0.90, and 1.02, respectively (P = .710).
Conclusions: In patients with advanced lung SCC, various regimens did not have a significant effect on survival outcomes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cllc.2014.09.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intensive electron transfer of a single-atom Fe-based catalytic ceramic membrane for municipal wastewater treatment: The synergistic effects of nitrogen vacancy defect and ultrathin nanostructure.
Water Res
December 2024
State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China. Electronic address:
The integration of membrane separation with heterogeneous advanced oxidation processes is a prospective strategy for the elimination of contaminants during wastewater treatment. Fe-based catalysts and the green oxidant peracetic acid (PAA) are desirable candidates for the development of catalytic membranes because they are environmentally friendly. However, the construction of catalytic ceramic membranes (CMs) modified with efficient Fe-based catalysts that generate increased amounts of high-valent Fe-O species during PAA activation for the degradation of specific pollutants, especially during instantaneous membrane filtration, remains challenging.
View Article and Find Full Text PDFBicarbonate ions promote rapid degradation of pollutants in Co(II)Fe(II)/peroxyacetic acid systems.
J Hazard Mater
December 2024
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, PR China. Electronic address:
Peroxyacetic acid (PAA), as an oxidizing agent, has gained significant attention in the field of advanced oxidation because of its low toxicity and high degradation capacity. In this study, cobalt-iron-based Prussian blue analogs (Co-PBAs) were utilized for the first time to activate PAA for tetracycline degradation. In the Co-PBAs/PAA system, organic radicals (RO•) and high-valent metal oxides are mainly produced.
View Article and Find Full Text PDFIntranasal influenza-vectored vaccine expressing pneumococcal surface protein A protects against Influenza and Streptococcus pneumoniae infections.
NPJ Vaccines
December 2024
Grupo Integrado de Pesquisa em Biomarcadores, Instituto René Rachou-Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brasil.
Streptococcus pneumoniae and influenza A virus (IAV) are significant agents of pneumonia cases and severe respiratory infections globally. Secondary bacterial infections, particularly by Streptococcus pneumoniae, are common in IAV-infected individuals, leading to critical outcomes. Despite reducing mortality, pneumococcal vaccines have high production costs and are serotype specific.
View Article and Find Full Text PDFStretchable and self-healing carboxymethyl cellulose/polyacrylic acid conductive hydrogels for monitoring human motions and electrophysiological signals.
Int J Biol Macromol
December 2024
State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China. Electronic address:
Stretchable conductive hydrogels have attracted great attention in flexible electronics. Nevertheless, conductive hydrogels would suffer from an inevitable damage during use, significantly reducing the reliability and limiting the practicability. Herein, stretchable and self-healing conductive hydrogels are designed form carboxymethyl cellulose (CMC), polyacrylic acid (PAA), and Fe, which are applied for monitoring human motions and electrophysiological signals.
View Article and Find Full Text PDFHighly stretchable, self-healing, adhesive, 3D-printable and antibacterial double-network hydrogels for multifunctional wearable sensors.
Int J Biol Macromol
December 2024
Guilin University of Technology, Coll Chem & Bioengn, Guangxi, Guilin 541004, China; Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China.
Conductive hydrogels based on sodium alginate (SA) have potential applications in human activity monitoring and personal medical diagnosis due to their good conductivity and flexibility. However, most sensing SA-hydrogels exhibit poor mechanical properties and lack of self-healing, self-adhesive, and antibacterial properties, greatly limiting their practical applications. Therefore, in this paper, a multifunctional double-network PAA-SA hydrogel consisting of poly(acrylic acid) (PAA) and sodium alginate (SA) was prepared by a simple strategy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!