AI Article Synopsis
- This study examined gene expression in the subcutaneous fat of Jinhua and Landrace pigs, finding higher levels of specific lipid-related genes in Jinhua pigs.
- Researchers identified a new gene, pFAM134B, which is significantly more abundant in Jinhua pigs and plays a crucial role in lipid accumulation.
- The findings suggest that pFAM134B regulates fat deposition by impacting various lipogenic and lipolytic genes, offering potential insights into managing fat accumulation and related disorders.
Article Abstract
In this study, we analyzed the global gene expression profiles in the subcutaneous fat (SAT) of Jinhua pigs and Landrace pigs at 90d. Several genes were significantly highly expressed in Jinhua pigs, including genes encoding the rate limiting enzymes in the TCA cycle, fatty acid activation, fatty acid synthesis and triglyceride synthesis. We identified a novel gene tagged by the EST sequences as public No. BF702245.1, which was named porcine FAM134B (pFAM134B) and the pFAM134B mRNA levels of SAT was significantly higher in Jinhua pigs than that in Landrace pigs at 90d (P<0.01). Then the effects of pFAM134B on lipid accumulation were investigated by using RNAi and gene overexpression in the subcutaneous adipocytes. The results showed that pFAM134B played a significant positive role in regulating lipid deposition by increasing the mRNA levels of PPARγ, lipogenic genes fatty acid synthetase (FAS) and acetyl-CoA carboxylase (ACC) (P<0.01) and reducing the mRNA levels of adipose triglyceride lipase (ATGL) and lipase, hormone-sensitive (HSL) (P<0.01). This study implied that pFAM134B might be a positive factor in lipid deposition, providing insight into the control of fat accumulation and lipid-related disorders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbrc.2014.10.117 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.
Imeta
December 2024
Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.
View Article and Find Full Text PDF[Wild boar resource and its conflict with human in Zhejiang Province, East China].
Ying Yong Sheng Tai Xue Bao
October 2024
College of Life Sciences, China Jiliang University, Hangzhou 310018, China.
Human-wildlife conflict is one of the important research topics in biodiversity and conservation. Understanding the status of wildlife resources and its conflict with human could promote the sustainable protection and management of wildlife. Wild boar () is one of the most widely distributed ungulates in the world, with an increasing population and recently rising levels of conflict with human.
View Article and Find Full Text PDFCurcumin protects porcine granulosa cells and mouse ovary against reproductive toxicity of aflatoxin B1 via PI3K/AKT signaling pathway.
Environ Pollut
December 2024
Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, 311300, China. Electronic address:
Aflatoxin B1 (AFB1) is a widespread food contaminant with toxic effects on female reproductive system. This concerns the human public health and the development of the livestock industry. Effective and feasible measures against reproductive toxicity of AFB1 are also unknown.
View Article and Find Full Text PDFAn Automatic Movement Monitoring Method for Group-Housed Pigs.
Animals (Basel)
October 2024
Zhongrun Agriculture and Animal Husbandry Technology (Zhejiang) Co., Ltd., Jinhua 321000, China.
Article Synopsis
- Continuous movement monitoring of pigs can quickly identify any abnormalities, ultimately improving their welfare; however, accurately tracking daily movements poses challenges on farms.
- The study utilized the YOLOv8m-seg model for detecting pigs and combined it with a spatial moment algorithm to analyze their movement by converting detected contours into center points.
- Over a period from April to July 2023, this method monitored the movements of group-housed pigs using over 1500 hours of video, achieving high accuracy with an F1 score exceeding 90% and maintaining efficient performance on standard hardware.
Decoding of the saltiness enhancement taste peptides from Jinhua ham and its molecular mechanism of interaction with ENaC/TMC4 receptors.
Food Chem
January 2025
School of Food and Biological Engineering, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei 230601, China; Shandong Delisi Food Co., Ltd, Weifang 262200, China. Electronic address:
This study focused on unlocking the potential of Jinhua ham-derived peptides (JHP) for enhancing saltiness. JHP (<3 kDa) was obtained through ultrafiltration and desalting, reducing the salt content by 96 %. Four peptide fractions (JHP-P1/P2/P3/P4) were isolated using Sephadex G-25 gel filtration and anion-exchange chromatography.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!