AI Article Synopsis
- This study aimed to assess whether a cyanoacrylate-based skin sealant (InteguSeal) could reduce bacterial contamination during trauma surgery, which is a known risk factor for surgical site infections (SSIs).
- A total of 128 patients were randomly assigned to either an intervention group that received the sealant or a control group, with bacterial counts measured at various surgical site locations after surgery.
- Results indicated significantly lower bacterial counts at the suture site in the intervention group compared to the control group, but overall wound contamination levels did not change, suggesting that while suture contamination was reduced, it may not greatly impact the prevention of deeper SSIs.
Article Abstract
Objective: Intraoperative bacterial contamination is a risk factor for surgical site infections (SSIs). This prospective, randomized, blinded, controlled trial (Reg. No. BB08/12) investigated the effect of a cyanoacrylate-based skin sealant (InteguSeal) on intraoperative wound contamination during trauma surgery.
Methods: A total of 128 patients undergoing trauma surgery were assigned randomly to an intervention (n=62) or a control group (n=66). Surgical sites were investigated at three locations: maximum incision depth (base), wound margin prior to wound closure (margin), and the surgical sutures (suture). Colony-forming units (CFU) were counted after 48h of incubation.
Results: Overall, significantly lower CFU counts were obtained for samples from the intervention group at all three sample sites compared to the control group. The difference, however, was only significant for the suture site (p=0.040).
Conclusions: Preoperative sealing reduced microbial contamination on sutures during surgery, while the overall wound contamination remained unchanged. Hence, prevention of the clinically more relevant deep SSIs may not be expected. However, this study was not designed to detect differences in the rate of SSI. The role of the reduction in suture contamination with regard to the prevention of SSI remains to be evaluated.
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| http://dx.doi.org/10.1016/j.ijid.2014.08.008 | DOI Listing |
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