AI Article Synopsis
- The study aimed to investigate if baseline measurements from the Heidelberg Retina Tomograph (HRT) are linked to the onset of open-angle glaucoma (OAG) in individuals with ocular hypertension.
- It analyzed data from 489 participants over a median follow-up of about 5 years, where 61 participants developed OAG, assessing various HRT parameters for their predictive value.
- Results indicated that specific HRT measurements, like cup depth and cup-to-disc ratios, were significantly associated with the likelihood of developing OAG, suggesting potential early indicators for at-risk individuals.
Article Abstract
Purpose: To determine whether baseline Heidelberg Retina Tomograph (HRT) measurements of the optic disc are associated with the development of open-angle glaucoma (OAG) in individuals with ocular hypertension in the European Glaucoma Prevention Study (EGPS).
Design: Retrospective analysis of a prospective, randomized, multicenter, double-masked, controlled clinical trial.
Methods: There were 489 participants in the HRT Ancillary Study to the EGPS. Each baseline HRT parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of OAG. Proportional hazards models were used to identify HRT variables that predicted which participants in the EGPS had developed OAG. Development of OAG was based on visual field and/or optic disc changes.
Results: At a median follow-up time of about 5 years, 61 participants developed OAG. In multivariate analyses, adjusting for randomization arm, age, baseline IOP, central corneal thickness, pattern standard deviation, and HRT disc area, the following HRT parameters were associated with the development of OAG: the "outside normal limits" classification of the Frederick Mikelberg (FSM) discriminant function (hazard ratio [HR] 2.51, 95% confidence interval [CI]: 1.45-4.35), larger mean cup depth (HR 1.64, 95% CI: 1.21-2.23), cup-to-disc area ratio (HR 1.43, 95% CI: 1.14-1.80), linear cup-to-disc ratio (HR 1.43, 95% CI: 1.13-1.80), cup area (HR 1.33, 95% CI: 1.08-1.64), smaller rim area (HR 1.33, 95% CI: 1.07-1.64), larger cup volume (HR 1.30, 95% CI: 1.05-1.61), smaller rim volume (HR 1.25, 95% CI: 1.01-1.54), larger maximum cup depth (HR 1.18, 95% CI: 1.01-1.36), and cup shape measure (HR 1.18, 95% CI: 1.01-1.36).
Conclusions: Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of OAG among the EGPS participants.
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| http://dx.doi.org/10.1016/j.ajo.2014.10.028 | DOI Listing |
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