Novel opportunities for the exploitation of host-microbiome interactions in the intestine.

Curr Opin Biotechnol

University of Antwerp, Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, Groenenborgerlaan 171, B-2020 Antwerp, Belgium; KU Leuven, Centre of Microbial and Plant Genetics, Kasteelpark Arenberg 20, Box 2460, B-3001 Leuven, Belgium. Electronic address:

Published: April 2015

New sequencing technologies have dramatically increased our knowledge on the composition of the human intestinal microbiota in health and disease. In parallel, various omics as well as focused molecular studies have revealed novel insights in host-microbiome interactions at the cellular and molecular level. Although these studies are mainly descriptive, advanced microbiota-targeting intervention strategies are being explored, ranging from the selection of novel probiotic strains and synthetic stool substitutes, toward the better monitoring of prebiotic and dietary interventions. It can be envisaged that the efficacy of microbiota interventions will depend on the status of the microbiota of an individual at baseline, but also on genetic and physiological host parameters that determine the capacity to interact with microbes via specific receptors.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.copbio.2014.10.008DOI Listing

Publication Analysis

Top Keywords

host-microbiome interactions
8
novel opportunities
4
opportunities exploitation
4
exploitation host-microbiome
4
interactions intestine
4
intestine sequencing
4
sequencing technologies
4
technologies dramatically
4
dramatically increased
4
increased knowledge
4

Similar Publications

The identification of novel bacterial species from the intestines of yaks residing on the Qinghai-Tibet Plateau is pivotal in advancing our understanding of host-microbiome interactions and represents a promising avenue for microbial drug discovery. In this study, we conducted a polyphasic taxonomic analysis and bioactive assays on a strain, designated Bos-x6-28, isolated from yak feces. The findings revealed that strain Bos-x6-28 shares a high 16S rRNA gene sequence similarity (98.

View Article and Find Full Text PDF

Unlabelled: The T cell receptor (TCR) repertoire of intestinal CD4+ T cells is enriched for specificity towards microbiome-encoded epitopes shared among many microbiome members, providing broad microbial reactivity from a limited pool of cells. These cells actively coordinate mutualistic host-microbiome interactions, yet many epitopes are shared between gut symbionts and closely related pathobionts and pathogens. Given the disparate impacts of these agents on host health, intestinal CD4+ T cells must maintain strain-level discriminatory power to ensure protective immunity while preventing inappropriate responses against symbionts.

View Article and Find Full Text PDF

Evidence suggests that a healthy gut microbiome is essential for metabolizing dietary phytochemicals. However, the microbiome's role in metabolite production and the influence of gut dysbiosis on this process remain unclear. Further, studies on the relationship among gut microbes, metabolites, and biological activities of phytochemicals are limited.

View Article and Find Full Text PDF

Apical periodontitis microbiome association with salivary and serum inflammatory burden.

Int Endod J

January 2025

Department of Endodontics, Centre of Oral Clinical and Translational Sciences, Faculty of Dentistry, Oral and Craniofacial Sciences, Guy's Dental Hospital, King's College London, London, UK.

Aims: Apical Periodontitis (AP) involves complex interactions between the root canal microbiome and the host immune response, with potential risk of local and systemic inflammatory burden, however there is no evidence available regarding correlation between microbiome and inflammatory marker levels. This study aims to identify the microbiome of saliva, intracanal and blood samples in AP subjects and investigate the correlation between intracanal and blood microbiomes with serum inflammatory biomarker levels, and salivary microbiomes with salivary inflammatory biomarker levels.

Methodology: Saliva, Intracanal and blood samples were collected from AP patients undergoing root canal retreatment.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!