AI Article Synopsis
- The study aimed to evaluate the effects of manuka honey on epidural fibrosis following laminectomy in rats, as epidural fibrosis is a common cause of failed back surgeries.
- Subjects were divided into two groups: one underwent laminectomy alone, while the other had laminectomy with manuka honey applied.
- Results indicated that the group treated with manuka honey had significantly less epidural fibrosis compared to the control group, suggesting its potential as a preventive treatment in clinical settings.
Article Abstract
Aim: One of the most important causes of failed back surgery is the development of epidural fibrosis. Many methods and substances have been used to prevent the development of epidural fibrosis after laminectomy. In this study, effects of "manuka honey" on epidural fibrosis development after laminectomy was evaluated in rats.
Material And Methods: Subjects were divided into two groups:In Group-1 (n=8);only laminectomy was carried out in the L1 level; in group-2 (n=8), laminectomy was carried out in the L1 level and manuka honey was applied to the area. The related vertebral columns were removed en bloc 6 weeks later. Leveled sections with thicknesses of 6 mm were obtained from paraffin blocks.
Results: In the grading made based on the fibroblast count and scar tissue degree, it was found that epidural fibrosis developed significantly less in the group-2 as compared to the group-1, and the difference was statistically significant.
Conclusion: It was shown in our study that manuka honey reduces the degree of epidural fibrosis in rats following laminectomy. We believe that manuka honey, which can be used safely in the clinic for surgical wounds, can be used routinely to prevent development of epidural fibrosis following laminectomy.
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| http://dx.doi.org/10.5137/1019-5149.JTN.8783-13.0 | DOI Listing |
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