AI Article Synopsis
- The study highlights the challenges of identifying single genes as diagnostic markers for glioblastoma (GBM), focusing on the role of EZH2.
- Increased levels of EZH2 were linked to higher tumor grades and shorter overall survival in GBM patients, indicating its potential as a prognostic marker.
- Repressing EZH2 was found to halt cell growth and promote a feedback loop with key signaling pathways, suggesting EZH2's promise as a therapeutic target in GBM.
Article Abstract
The identification of single or less genes based on mRNA expression as clinical diagnostic markers for glioblastoma (GBM) remains a challenge. Recent data have shown the potential oncogenic role and prognostic significance of EZH2 in several human cancers. However, the clinical signature and further mechanisms of EZH2 function in gliomagenesis are still poorly understood. In this study, we found that increased EZH2 expression was associated with tumor grade. High expression of EZH2 in GBM was determined to be a strong and independent predictor of short overall survival. Further, we screened EZH2 targets and associated genes in GBM. Repression of EZH2 induced cell cycle arrest and inhibited tumor growth in vivo. This event represents a positive feedback loop with β-catenin/TCF4 and STAT3 signaling. Taken together, EZH2 could be an independent prognostic factor and potential therapeutic target for GBM.
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| http://dx.doi.org/10.1016/j.canlet.2014.11.003 | DOI Listing |
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