AI Article Synopsis
- Craniosynostosis is a condition where one or more skull sutures close too early due to genetic and environmental factors, with isolated cases usually being sporadic while most syndromic cases involve FGFR mutations.
- The article reviews the causes and clinical forms of both isolated and syndromic craniosynostosis, including a brief look at the genetics involved.
- It also explores past and current surgical techniques, evaluates recent outcome data, and discusses ongoing controversies and promising developments in craniofacial surgery.
Article Abstract
Craniosynostosis, in which 1 or more cranial sutures prematurely fuse, is associated with diverse environmental and genetic factors. Whereas isolated single-suture synostosis is usually sporadic and nonfamilial, FGFR mutations account for most cases of syndromic craniosynostosis. This article reviews the etiology and various clinical manifestations of the most common isolated and syndromic forms of craniosynostosis, and provides a brief overview of genetics. Past and present surgical management approaches and techniques are examined in depth. Outcomes data in the recent literature are reviewed, and controversies in the field and promising trends in craniofacial surgery discussed.
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| http://dx.doi.org/10.1016/j.fsc.2014.08.002 | DOI Listing |
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