To effectively treat an aging and increasingly complex patient population, emergency physicians and other acute-care providers must be comfortable with the use of vasopressors, inotropes, and chronotropes. These medicines are used to augment the cardiovascular function of critically ill patients. Each class of medication produces a different hemodynamic effect. Some agents produce only one of these actions, whereas others have multiple effects. For the emergency physician, these agents are used with the explicit goal of preserving vital organ perfusion during acute and severe illness. This article reviews the physiologic receptors targeted by such drugs, common agents used, and specific clinical indications for their use.
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http://dx.doi.org/10.1016/j.emc.2014.07.006 | DOI Listing |
Front Physiol
January 2025
Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan.
Introduction: The effect of mechanoreflex on central blood pressure (BP) is unclear, although the influence of metaboreflex has been investigated. A relatively small contribution of the mechanoreflex to the pressor response to exercise has been considered in humans because many studies have failed to isolate the mechanoreflex-mediated pressor response. In a recent study, we successfully isolated a mechanoreflex-mediated pressor response using static passive stretching (SPS) in the forearm.
View Article and Find Full Text PDFMed Sci Sports Exerc
December 2024
Integrative Physiology Laboratory, Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL.
Introduction: Individuals with Down syndrome (DS) exhibit autonomic dysfunction, which contributes to reduced work capacity. The metaboreflex produces exercise-induced sympathoexcitation and can be assessed via post-exercise muscle ischemia (PEMI). Blunted sympathoexcitation is common in individuals with DS and contributes to the physiological basis for reduced work capacity observed this population, but the influence of the metaboreflex is unknown.
View Article and Find Full Text PDFJ Physiol
November 2024
Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
Psychophysiology
December 2024
Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Eur J Appl Physiol
September 2024
İstanbul Physical Therapy Rehabilitation Training and Research Hospital, Adnan Kahveci Blv. No : 145, Bahçelievler, 34186, Istanbul, Turkey.
Background: Although brief skin cooling (BSC) is widely used in sports medicine and rehabilitation for its positive effects on motor performance, the mechanism underlying this motor facilitation effect remains unclear.
Objectives: To explore the hypothesis that BSC enhances muscle force generation, with cold-induced sympathetic activation leading to heightened muscle spindle sensitivity, thereby contributing to this effect.
Methods: The study involved two experiments.
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