In order to assess whether the concentration of high density lipoproteins (HDLs) changes in leishmaniotic dogs before and after treatment, HDL cholesterol (HDL-Chol and HDL%), C reactive protein (CRP) and activity of the antioxidant enzyme paraoxonase (PON-1) were measured in sera from 10 controls and 10 leishmaniotic dogs. Seven of these latter were sampled also 3, 7, 14, 21 and 28 days after treatment with antimonials and allopurinol. HDL-chol, and PON-1 were low in leishmaniotic dogs at admission and increased after treatment. HDL-chol and HDL% correlated positively with PON-1 and negatively with CRP suggesting that HDLs decrease through an oxidative mechanism. Therefore, HDLs may be used to monitor the magnitude of oxidation associated with inflammation in leishmaniotic dogs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rvsc.2014.11.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of a combination of nucleotides and lactoferrin in maintaining stable or improving the clinical picture and laboratory findings of leishmaniotic dogs: A randomized controlled study.
Vet Parasitol
December 2024
Department of Veterinary Medicine, University of Bari, Valenzano 70010, Italy. Electronic address:
This prospective, randomized, controlled, therapeutic study aimed to evaluate the efficacy of a product containing nucleotides and lactoferrin in maintaining or improving the clinical picture and laboratory findings of canine leishmaniosis (CanL). The safety and tolerance of this combination were also assessed. Forty Leishmania infantum-seropositive dogs, not requiring leishmanicidal and/or leishmaniostatic treatment, were enrolled in the study and randomized into treatment (TG) and placebo (CG) groups.
View Article and Find Full Text PDFAssessment of circulating immune complexes in canine leishmaniosis and dirofilariosis.
Vet Res Commun
June 2023
Department of Veterinary Medicine, University of Bari, Valenzano, 70010, Bari, Italy.
Canine leishmaniosis (CanL) by Leishmania infantum (L.i.) and heartworm disease by Dirofilaria immitis (D.
View Article and Find Full Text PDFEfficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis.
Parasit Vectors
October 2022
Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
Background: Chronic kidney disease (CKD) represents the main cause of mortality in dogs with leishmaniosis. Domperidone has recently been reported to improve kidney function in leishmaniotic dogs affected by CKD. Serum symmetric dimethylarginine (sSDMA) has also been shown to be a useful biomarker for earlier detection of decreased kidney function when compared to serum creatinine (sCr).
View Article and Find Full Text PDFMicroautophagy upregulation in cutaneous lymph nodes of dogs naturally infected by Leishmania infantum.
Parasitol Res
July 2020
Dipartimento di Medicina Veterinaria e Produzioni Animali, Università di Napoli Federico II, Napoli, Italy.
This is the first study showing an in vivo microautophagy upregulation by Leishmania infantum in dogs. Both Leishmania amastigotes and promastigotes were detected in the cytoplasm of many professional and nonprofessional phagocytic cells of popliteal lymph node of three dogs suffering from chronic cutaneous leishmaniasis. Ultrastructurally, parasites appeared to be wrapped by lysosomes and/or multivesicular bodies.
View Article and Find Full Text PDFExpression of Serum Exosomal miRNA 122 and Lipoprotein Levels in Dogs Naturally Infected by : A Preliminary Study.
Animals (Basel)
January 2020
Department of Experimental and Clinical Medicine Magna Graecia University, 88100 Catanzaro, Italy.
Current knowledge on the role of exosomal microRNA (miRNA) in canine leishmaniasis (CL), with particular regards to the interaction between miR-122 and lipid alterations, is limited. The aim of this study was to isolate/characterize exosomes in canine serum and evaluate the expression of miR-122 in ten healthy and ten leishmaniotic dogs. Serum exosomes were isolated using a polymer-based kit, ExoQuick and characterized by flow cytometry and transmission electron microscopy, whereas miR-122-5p expression was evaluated by quantitative reverse-transcriptase polymerase chain reaction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!