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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease.
Cell Host Microbe
December 2024
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, especially adherent-invasive Escherichia coli (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promotes intestinal fibrosis in an IBD mouse model.
View Article and Find Full Text PDFPrenatally Diagnosed Intralobar Pulmonary Sequestration With a Gastric Foregut Duplication Cyst.
Pediatr Pulmonol
December 2024
Department of Pediatric Surgery, University of Tsukuba, Tsukuba, Japan.
Adult pulmonary sequestration: a hidden cause of recurrent hemoptysis (case report).
Pan Afr Med J
December 2024
Pneumology Department, University Hospital Farhat Hached, Sousse, Tunisia.
Pulmonary sequestration (PS) is a rare congenital malformation where abnormal lung tissue lacks a connection to the airways and receives blood supply from systemic arteries. This case report describes a 30-year-old man with recurrent hemoptysis diagnosed with intralobar PS (ILS) as the cause. He underwent video-assisted thoracoscopic surgery to clip and section the aberrant artery, resulting in a successful outcome with no further bleeding.
View Article and Find Full Text PDFFactors affecting inflammatory changes in congenital lung malformations.
Pediatr Surg Int
December 2024
Neurofarba Department, University of Florence, Florence, Italy.
Aim Of The Study: Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.
View Article and Find Full Text PDFIntrathoracic ectopic kidney with pulmonary sequestration: clinical and surgical insights: a case report.
J Surg Case Rep
December 2024
Pediatric Surgery Center, National Ribat University Hospital, Khartoum, Sudan.
Intrathoracic ectopic kidney is an extremely rare congenital defect that is frequently identified by accident because it is asymptomatic. Even more unusual is its link to pulmonary sequestration alone. This case report describes the clinical presentation of a 7-month-old child with a history of recurrent respiratory distress and chest infections since birth, who had shortness of breath, failure to thrive, and delayed developmental milestones.
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