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Aged Garlic Extract (AGE) and Its Constituent S-Allyl-Cysteine (SAC) Inhibit the Expression of Pro-Inflammatory Genes Induced in Bronchial Epithelial IB3-1 Cells by Exposure to the SARS-CoV-2 Spike Protein and the BNT162b2 Vaccine.
Molecules
December 2024
Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.
Garlic ( L.) is a species of the onion family () widely used as a food and a folk medicine. The objective of this study was to determine the effects of AGE (aged garlic extract) on pro-inflammatory genes relevant to COVID-19.
View Article and Find Full Text PDFAssessment of air pollutant O pulmonary exposure using a bronchus-on-chip model coupling with atmospheric simulation chamber.
J Hazard Mater
January 2025
Laboratory of Atmospheric Environment and Pollution Control (LAEPC), Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Heavy air pollution is now a serious public health issue. Many studies have shown strong connections between ozone (O) with the occurrence and development of various respiratory diseases. However, the exact mechanism is still a matter of debate.
View Article and Find Full Text PDFIntranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection.
Antiviral Res
January 2025
INSERM, Research Center for Respiratory Diseases, UMR 1100, University of Tours, France. Electronic address:
The respiratory tract hosts a diverse microbial community whose composition varies with anatomical location and throughout life. Rothia mucilaginosa, a common commensal of the upper respiratory tract and oral cavity, has recently been recognized for its ability to inhibit bacteria-triggered pro-inflammatory responses. However, its role in modulating the immune response to viral infections such as influenza A virus (IAV) pneumonia, remains unknown.
View Article and Find Full Text PDFDidecyldimethylammonium chloride-induced lung fibrosis may be associated with phospholipidosis.
Toxicol Appl Pharmacol
December 2024
College of Medicine, Graduate School, Kyung Hee University, 02447, Republic of Korea; Human Health and Environmental Toxins Research Center, Kyung Hee University, 02447, Republic of Korea. Electronic address:
In the current study, we dosed didecyldimethylammonium chloride (DDAC) in mice by pharyngeal aspiration for 28 days or 90 days (weekly) and tried to elucidate the relationship between lamellar body formation and the lesions. When exposed for 28 days (0, 5, 10, 50, and 100 μg/head), all the mice in the 50 and 100 μg/head groups died since Day 2 after the third dosing (Day 16 after the first dosing). Edema, necrosis of bronchiolar and alveolar epithelium, and fibrinous exudate were observed in the lungs of all the dead mice, and chronic inflammatory lesions were observed in the lung tissues of alive mice.
View Article and Find Full Text PDFIndole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways.
J Mol Med (Berl)
December 2024
Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Shengli Road 804, Xingqing District, Yinchuan, 750004, Ningxia, China.
Indole-3-aldehyde (I3A) is an intestinal microbial metabolite that regulates inflammation in various inflammatory diseases; however, its role in chronic obstructive pulmonary disease (COPD) remains unclear. This study aimed to investigate the anti-inflammatory effects and molecular mechanisms of I3A in COPD. We constructed in vivo models using cigarette smoke (CS)-stimulated mice and in vitro models using cigarette smoke extract (CSE)-stimulated MH-S cells.
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