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Hepatitis B virus infection and the risk of male infertility: a population-based analysis. | LitMetric

Hepatitis B virus infection and the risk of male infertility: a population-based analysis.

Fertil Steril

Department of Public Health, China Medical University, Taichung, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. Electronic address:

Published: December 2014

Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection.

Design: A nationwide, population-based cohort study.

Setting: Not applicable.

Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690).

Intervention(s): None.

Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification.

Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.

Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

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Source
http://dx.doi.org/10.1016/j.fertnstert.2014.09.017DOI Listing

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