The aim of the study described here was to examine the potential of tomography ultrasonography imaging (TUI) in evaluation of the fetal anal sphincter. In this prospective cross-sectional study of the fetal anal sphincter with TUI, 326 singleton pregnancies (mean age = 28 y, range: 22-38 y) were scanned at 19-40 wk of gestation. The fetal anal region and ischium were revealed in 320 of 326 patients (98.2%). The normal fetal anal sphincter diameter and ischial space reached maximums of 15 and 39 mm, respectively. The normal fetal anal sphincter diameter and the ischial space were plotted as a function of gestational age (GA) on a linear curve, and the regression equations for normal fetal anal sphincter diameter and ischial space as a function of GA in weeks were obtained. A scatterplot was also created that revealed a significant positive relationship between normal fetal anal sphincter diameter and ischial space. On the basis of these criteria, imperforate anus was diagnosed in one fetus. Ultrasonographic assessment of the fetal anal sphincter and the ischium with TUI is feasible. The reference values reported in this article may be useful in prenatal diagnosis of fetal anal sphincter abnormalities.
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http://dx.doi.org/10.1016/j.ultrasmedbio.2014.07.017 | DOI Listing |
Anal Methods
January 2025
Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 200092, China.
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder that typically leads to severe pregnancy outcomes. Although genetic, endocrine, and environmental factors are involved in the etiology of ICP, the role of metabolic disorders remains unclear. Here we report an examination of the biomolecular alterations in placental tissues of women with ICP and healthy pregnant women at a molecular level.
View Article and Find Full Text PDFAnal Chem
January 2025
Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara 06230, Turkey.
Metabolite levels and turnover rates are necessary to understand metabolomic dynamics in a living organism fully. Amino acids can play distinct roles in various cellular processes, and their abnormal levels are associated with pathological conditions, including cancer. Therefore, their levels, especially turnover rates, may provide enormous information about a phenotype.
View Article and Find Full Text PDFJ Clin Lab Anal
January 2025
Department of Laboratory Medicine, The Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: Hepatocellular carcinoma (HCC) is a ubiquitous malignancy linked to significant mortality. The abnormal expression of β-1,4-N-acetyl-galactosaminyltransferase 1 (B4GALNT1) seemed to be implicated in tumorigenesis. Nonetheless, this enzyme's roles in HCC are unclear.
View Article and Find Full Text PDFCureus
December 2024
Yoga and Cranial Osteopathy, ApsDEHA, Savona, ITA.
Childbirth is a dynamic process involving mutual adaptation between the maternal pelvis and the presenting fetal part. The ability of the pelvis to maintain optimal mobility during labor plays a crucial role in achieving favorable obstetric outcomes. The pubic arch angle (PAA) increases amplitude during pregnancy, showing pelvic tissue adjustment.
View Article and Find Full Text PDFJ Gynecol Obstet Hum Reprod
January 2025
Department of Obstetrics and Gynecology, Poitiers University Hospital, 2 Rue de la Milétrie, Poitiers 86000, France; INSERM, CIC 1402, Poitiers University Hospital; Poitiers University, Poitiers, France.
Aims: Ultrasound is used in the delivery room to assess fetal head position, engagement during labor, and anal sphincter injuries in the immediate postpartum period. The transperineal approach allows for direct visualization of the structures of interest without altering anatomical landmarks. Various ultrasound measurements during labor have been described in the literature, and their use varies widely across maternity units.
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