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Introduction: Ipilimumab is an anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) antibody. Ipilimumab has shown improvement in overall survival in patients with advanced melanoma. Because ipilimumab activates the immune system against the tumor, ipilimumab is associated with adverse events related to immune system activation.

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Sweet's syndrome in a patient with metastatic melanoma after ipilimumab therapy.

Melanoma Res

December 2013

Departments of aHematology and Medical Oncology bPathology, Mount Sinai School of Medicine, New York, New York, USA.

Sweet's syndrome, a neutrophilic dermatosis, is a known paraneoplastic complication occurring with various malignancies. It has been infrequently reported in association with melanoma. Ipilimumab is an antibody against an inhibitory cytotoxic T-lymphocyte-associated antigen 4 receptor on T cells.

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