AI Article Synopsis
- Histone demethylases, discovered in 2004, are crucial for regulating chromatin and have been linked to various biological processes through their interaction with signaling pathways.
- Recent research focusing on mutant animals has provided new insights into the different families of histone demethylases and their biological functions.
- Understanding how these demethylases interact with environmental signals to influence chromatin can enhance our knowledge of normal cellular processes and aid in developing new cancer therapies targeting epigenetic changes.
Article Abstract
Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to reveal the interconnections between histone demethylases and signaling pathways, suggesting that this interplay drives fundamental biological processes. Here, we summarize the different families and subfamilies of histone demethylases and the insights into the biological roles of these enzymes that have been provided by the analysis of mutant animals. We then review recent work linking demethylases and signaling pathways. These studies suggest that demethylase activities are a component of the critical connections that enable environmental signals to modulate the epigenetic landscape of a cell. A greater mechanistic understanding of the network of signals that control chromatin states during normal cellular processes, together with a better understanding of the ways that epigenetic alterations lead to uncontrolled cell proliferation, might help in the design of effective tools for cancer therapy.
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