Background: Chai Hu has the hepato-protective, choleretic, anti-tussive, analgesic, anti-inflammatory, anti-viral, hypotensive, hypolipidemic, and anti-tumor pharmacological effects. In this study, the objective of this paper was to study the anti-depressant effect of total saikosaponins.
Materials And Methods: Total saikosaponins were extracted by reflux method, and were identified by thin layer chromatography (TLC). The anti-depressant effect of total saikosaponins was investigated in vitro by tail suspension test, forced swimming test, and reserpine antagonism test in mice.
Results: Two times of reflux extraction, temperature of 70°C, and extraction time of 4hrs, for each extraction could improve the yield of saikosaponins. Each treatment group (100, 200, and 300 mg/kg), could significantly shorten the immobility time of mice in the tail suspension test in a somewhat dose-dependent manner. The total saikosaponins antagonized the reserpine-induced akinesia, and ptosis in mice.
Conclusion: Total saikosaponins have an anti-depressant effect.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202633 | PMC |
| http://dx.doi.org/10.4314/ajtcam.v11i2.9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating the Therapeutic Mechanisms of Total Saikosaponins in Alzheimer's Disease: A Metabolomic and Proteomic Approach.
Pharmaceuticals (Basel)
January 2025
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Alzheimer's disease (AD) is the leading cause of dementia among the elderly, yet effective treatments remain elusive. Total saikosaponins (TSS), the primary bioactive components in , have shown promising therapeutic effects against AD in previous studies. : To delve deeper into the mechanisms underlying the therapeutic role of TSS in AD, we investigated its neuroprotective effects and associated molecular mechanisms in APP/PS1 mice.
View Article and Find Full Text PDFSaikosaponin inhibits Eimeria tenella infection by modifying the NF-κB pathway and regulating cytokines and the intestinal microbial community.
Exp Parasitol
December 2024
College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China; Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China. Electronic address:
Eimeria tenella (E. tenella) is an intestinal parasite that not only endangers the health of broiler chickens but may also cause death in severe cases. However, the growing critical problem of drug resistance in E.
View Article and Find Full Text PDFThe AMPK-mTOR Pathway Is Inhibited by Chaihu Shugan Powder, Which Relieves Nonalcoholic Steatohepatitis by Suppressing Autophagic Ferroptosis.
Mediators Inflamm
November 2024
Jinan University, Guang Zhou 510632, China.
Nonalcoholic steatohepatitis (NASH) is the advanced stage of nonalcoholic fatty liver disease (NAFLD), which is distinguished by the accumulation of fat in the liver, damage to liver cells, and inflammation. Chaihu Shugan powder (CSP), a renowned traditional Chinese medicine (TCM) blend extensively utilized in China to address liver disease, has demonstrated its efficacy in reducing lipid buildup and effectively combating inflammation. Hence, the primary objective of this research is to examine the impacts and possible mechanisms of CSP on NASH through assessments of liver histopathology, lipidomic analysis, and gene expression.
View Article and Find Full Text PDFExploring Si-Ni-San's therapeutic mechanism in autoimmune thyroid diseases: A network pharmacology approach and experimental evidence.
J Ethnopharmacol
February 2025
Binzhou Medical University, Binzhou, Shandong, China; Binzhou Hospital of Traditional Chinese Medicine, Binzhou, Shandong, China. Electronic address:
Ethnopharmacological Relevance: Autoimmune thyroid diseases (AITD), a group of prevalent and persistent immune-mediated disorders affecting the endocrine system, can progressively result in total thyroid failure, thereby drastically impacting metabolic processes. Given the inadequacies of current clinical approaches to managing AITD, The exigency to investigate novel therapeutic strategies demands immediate attention, given the limitations and potential resistances associated with conventional approaches. Si-Ni-San (SNS), first chronicled in the esteemed Eastern Han Dynasty medical text " Treatise on Cold Damage and Miscellaneous Diseases" circa 200-210 AD, is a time-honored remedy known for its harmonizing effects on the liver and invigorating properties for the spleen.
View Article and Find Full Text PDFInsight into the compositional variation of volatile and polar compounds of Radix Bupleuri from different processing technologies by GC-MS and UHPLC-Q-TOF/MS metabolomics.
Phytochem Anal
September 2024
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, China.
Article Synopsis
- The study examines the active ingredients in Radix Bupleuri (RB) to understand how different processing methods affect their efficacy, which is crucial for developing traditional Chinese medicine (TCM).
- The researchers processed RB using rice vinegar, rice wine, and honey, and employed advanced chromatography techniques to analyze the changes in its polar and volatile compounds.
- A total of 30 polar and 33 volatile components were identified as key chemical markers, which could explain the distinct pharmacological effects of RB, paving the way for better clinical applications of TCM.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!