Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration.

Linda Gibbons Sara Rollinson Jennifer C Thompson Andrew Robinson Yvonne S Davidson Anna Richardson David Neary Stuart M Pickering-Brown Julie S Snowden David M A Mann

Neurobiol Aging

Faculty of Human and Medical Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK; Cerebral Function Unit, Department of Neurology, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK. Electronic address:

Published: March 2015

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504979	PMC
http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.023	DOI Listing

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