The antagonistic activity of strains Bacillus amyloliquefaciens YKM B-7243 and YKM B-7404 against bacterial and fungal agents of winter wheat diseases was demonstrated. Low antagonistic level against bacterial agents of plant diseases was shown. Antifungal activity of strains against agents of winter wheat was on the low level. High biological efficiency was shown under binary compositions of the studied strains. It was concluded that the enhancing of fungicide and growth-stimulation effects in binary compositions were found.

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