We report two cases of non-smoker patients diagnosed with EGFR-mutated lung adenocarcinoma and bearing germinal TP53 gene mutation, also known as Li-Fraumeni syndrome (LFS). We describe for the first time an EGFR-TKI resistance mutation in this population. Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database and from all the published cases of EGFR-mutated lung cancer in TP53 germline mutation carriers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lungcan.2014.11.005 | DOI Listing |
Publication Analysis
Top Keywords
lung adenocarcinoma
8
li-fraumeni syndrome
8
report cases
8
egfr-mutated lung
8
efgr-mutant lung
4
adenocarcinoma li-fraumeni
4
syndrome report
4
cases review
4
review literature
4
literature report
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!