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PKA inhibition is a central step in D,L-methadone-induced ER Ca release and subsequent apoptosis in acute lymphoblastic leukemia.
Front Cell Dev Biol
April 2024
Department of Cell Biology and Anatomy, Arnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, University of Calgary, Calgary, AB, Canada.
Acute lymphoblastic leukemia (ALL) is a hematologic cancer that mostly affects children. It accounts for over a quarter of ALL pediatric cancers, causing most of the cancer death among children. Previously, we demonstrated that D,L-methadone causes ALL cell apoptosis via μ-opioid receptor 1 (OPRM1)-triggered ER Ca release and decrease in Ca efflux, elevating [Ca].
View Article and Find Full Text PDFMethadone-Induced Hypoglycemia in a Hospitalized Patient.
Hosp Pharm
April 2024
Jr. Veterans Affairs Medical Center, Memphis, TN, USA.
Methadone is used as an agent for chronic pain and management of opioid use disorder. While similar pharmacologically to other opioids, methadone does have unique characteristics, including long half-life, low cost, and high oral bioavailability. While advantageous in some ways, methadone is associated with unique adverse effects not seen with other opioids (ie, hypoglycemia).
View Article and Find Full Text PDFPunica granatum Seed Essential Oil Suppressed Methadone-Induced Cell Death by Natural Antioxidant Activity.
Asian Pac J Cancer Prev
March 2023
Department of Medicinal Plant, Kermansha ACECR Institute of Higher Education, KErmanshah, Iran.
Objectives: Methadone is an opioid used in treating chronic and acute pains as well as opioid dependence. It induces death in neural cells. This study investigates Punica granatum oil's effects as a natural antioxidant on methadone-induced cell death.
View Article and Find Full Text PDFAcute Hydronephrosis Secondary to Methadone-Induced Constipation.
Cureus
May 2022
Medicine, Montefiore Medical Center, Wakefield Campus, Bronx, USA.
Article Synopsis
- - Opioid-induced constipation is a major issue, affecting 40% to 60% of patients on opioids without cancer, leading to severe complications.
- - A 71-year-old man with a history of opioid use disorder, treated with methadone, developed severe constipation and fecal impaction that caused ureter compression and right hydronephrosis.
- - His condition improved significantly through an aggressive bowel regimen involving stool softeners, laxatives, and enemas, highlighting the risks associated with methadone treatment.
Methadone-Induced Polymorphic Ventricular Tachycardia Complicated by Takotsubo Cardiomyopathy in a Malnourished Patient.
J Investig Med High Impact Case Rep
October 2021
Wayne State University, Detroit, MI, USA.
Takotsubo cardiomyopathy (TC) is a syndrome characterized by acute and transient regional systolic myocardial dysfunction. TC often mimics myocardial infarction without obstructive coronary disease. We present a case of a 48-year-old woman who developed TC following the onset of polymorphic ventricular tachycardia in the setting of methadone intoxication.
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