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Effective Treatment With Oral Propranolol for Congenital Intracranial Hemangioma in a Neonate: A Case Report and Literature Review.
Cureus
December 2024
Department of Pediatrics, The Jikei University School of Medicine, Tokyo, JPN.
Congenital intracranial hemangiomas are rare benign vascular tumors that develop before birth. Although various treatments, including surgery, steroids, interferon-α, thalidomide, bevacizumab, or propranolol, have been reported, no standard therapy has been established. We report the case of a neonate with congenital intracranial hemangioma and central nervous system symptoms requiring therapeutic intervention.
View Article and Find Full Text PDFEfficacy and safety of propranolol tablets vs. oral solution in neonates with severe infantile hemangiomas: a retrospective study in China.
Sci Rep
January 2025
Department of Plastic Surgery, Jiangxi Provincial Children's Hospital, 1666 Diezihu Avenue, Nanchang, China.
The objective of this study was to evaluate the efficacy and safety of propranolol hydrochloride tablets and oral solution in neonates with severe IHs. A retrospective cohort study included 184 consecutive neonates diagnosed with severe IHs and treated with propranolol from January 2016 to June 2023. Of these, 126 patients received propranolol tablets, and 58 received propranolol oral solution.
View Article and Find Full Text PDFCalibre Persistent Labial Artery of the Lower Lip: Oral Propranolol as a Novel Agent of Treatment.
J West Afr Coll Surg
July 2024
Department of Public Health, Southern Connecticut State University, New Haven, CT, USA.
Calibre persistent artery of the lower lip is a vascular anomaly where the branches of the inferior labial artery maintain their size up to the submucosa of the lip. There is persistent pulsatile feeling, occasional ulceration, and recurrent bleeding. Doppler ultrasound and angiogram are used to confirm diagnosis.
View Article and Find Full Text PDFManagement of Orofacial Infantile Haemangioma: A Case Report.
Case Rep Dent
December 2024
Department of Paediatric Dentistry, Selayang Hospital (Ministry of Health), Batu Caves, Selangor, Malaysia.
Infantile haemangioma (IH) is the most common childhood tumour, often developing in the head and neck region. It may cause disfigurement, functional impairment, or tooth developmental issues when it is present in the oral cavity. We report a case of a 2-month-old boy referred to the paediatric dentistry team with a segmental IH involving the left periorbital, cheek, and hard palate.
View Article and Find Full Text PDFEfficacy and safety of oral propranolol and topical timolol in the treatment of infantile hemangioma: a meta-analysis and systematic review.
Front Pharmacol
December 2024
Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou Medical University, Guangzhou, China.
Background: Propranolol, a nonselective β-blocker, is the first-line treatment for infantile hemangioma (IH). Topical timolol has recently been proposed as a novel IH treatment with fewer adverse effects. This study was conducted to compare the efficacy and safety of oral propranolol and topical timolol for treating IH.
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