Biological model of hypoxia can be used for the diagnosis of functional changes in human erythrocytes under the effect of the hypoxic factor. The use of this model together with modern methods of scanning probe microscopy for evaluation of the severity of pulmonological disease in senile patients will help to predict treatment efficiency and outcome.
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http://dx.doi.org/10.1007/s10517-014-2735-2 | DOI Listing |
Alzheimers Dement
December 2024
Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
Background: Recent single-cell omics analyses have revealed that microglia change into reactive microglia when Aβ accumulates in the brain and exhibit Aβ phagocytosis. However, reactive microglia are less likely to be induced in TREM2 mutation carriers. This microglia-centred pathological mechanism may be considered one of the pathologies of AD.
View Article and Find Full Text PDFAdv Gerontol
January 2025
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo av., St. Petersburg 197119, Russian Federation, e-mail:
One of the positive aspects of the implementation of laboratory information systems (LIS) in a medical organization, according to the plan of the Federal project of the Ministry of Health of the Russian Federation to create a unified digital circuit in healthcare, is the emergence of the ability to download large amounts of laboratory research data and analyze them. The purpose of the work is to assess the possibility of a unified digital circuit in providing operational monitoring of carbohydrate metabolism in middle-aged, elderly and senile people in the context of COVID-19. The materials used are the primary data of laboratory research results from the LIS «Ariadna.
View Article and Find Full Text PDFAdv Gerontol
January 2025
Samara State Medical University, 89 Chapayevskaya str., Samara 443099, Russian Federation, e-mail:
According to the federal register, up to 3,77 million elderly Russians have a confirmed diagnosis of type 2 diabetes mellitus (DM2), the most important criterion for the effectiveness of treatment of which is the achievement of therapeutic control targets. At the same time, the structure of the algorithm for their assessment in elderly patients is quite complex and involves the analysis of many different parameters, including indicators of geriatric status. The aim of the study was to develop a digital clinical calculator for determining individual goals of DM2 control in elderly patients based on the principles of evidence-based medicine.
View Article and Find Full Text PDFAdv Gerontol
January 2025
Research Medical Centre «Gerontology», 116, 1, 321 Volokolamskoe highway, Moscow 125371, Russian Federation.
The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.
View Article and Find Full Text PDFAim: Study the effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients after pneumonia associated with a new coronavirus infection (COVID-19) at the outpatient stage.
Materials And Methods: A prospective observational randomized study involving 66 patients (45 women and 21 men, average age 66.5±5.
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