Introduction: The increase in working age has many epidemiological consequences, one of which is an increased incidence of neoplastic diseases among the working population. Therefore it is more frequent than in the past that the Approved Physician ("Autorizzato" according to Italian legislation) have to judge working fitness in employees suffering from cancer and at the same time exposed to ionizing sources.
Aims: In this study we give suggestions for the decision if a worker, who have previously suffered from malignant tumors, is ready to go or not to go back to work.
Methods: Though we believe in the preventive theory of the linear correlation without threshold for stochastic effects ("Linear No Threshold" LNT), we considered data from the literature that highlight how very low doses of radiation exposure do not increase the risk of stochastic effects and how the potential occupational exposure to low doses does not introduce a significant additional risk of cancer in subjects with a history of malignant tumor.
Results: We identify "objective" elements of judgment related to the neoplastic disease of the worker and his activity, but we emphasize the importance of the psychological condition of the worker, as well as his professional interest and his career opportunities.
Conclusions: The criteria we recommend were applied to a group of workers suffering from cancer and with different working activities at risk of exposure to ionizing radiations. The evaluation process is a first rational approach to the assessment of their suitability in worker suffering from neoplastic disease, with the need for custom handling for each individual.
Download full-text PDF |
Source |
---|
Cancer Biol Ther
December 2025
Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Early and precise diagnosis of cancer is pivotal for effective therapeutic intervention. Traditional diagnostic methods, despite their reliability, often face limitations such as invasiveness, high costs, labor-intensive procedures, extended processing times, and reduced sensitivity for early-stage detection. Electrochemical biosensing is a revolutionary method that provides rapid, cost-effective, and highly sensitive detection of cancer biomarkers.
View Article and Find Full Text PDFFASEB J
March 2025
Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Neuron-derived clone 77 (Nur77), a member of the orphan nuclear receptor family, is expressed and activated rapidly in response to diverse physiological and pathological stimuli. It exerts complex biological functions, including roles in the nervous system, genome integrity, cell differentiation, homeostasis, oxidative stress, autophagy, aging, and infection. Recent studies suggest that Nur77 agonists alleviate symptoms of neurodegenerative diseases, highlighting its potential as a therapeutic target in such conditions.
View Article and Find Full Text PDFFASEB J
March 2025
Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.
The ribophorin family, including RPN1, has been associated with tumor progression, but its specific role in pan-cancer dynamics remains unclear. Using data from TCGA, GTEx, and Ualcan databases, we investigated the relationship of RPN1 with prognosis, genomic alterations, and epigenetic modifications across various cancers. Differential analysis revealed elevated RPN1 expression in multiple cancer types, indicating a potential prognostic value.
View Article and Find Full Text PDFCancer Med
March 2025
Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Introduction: Distress is common among cancer patients, especially those undergoing surgery. However, no study has systematically analyzed distress trends in this population. The purpose of this study was to systematically review perioperative rates of distress, as well as differences across cancer types, in cancer patients undergoing surgical intervention.
View Article and Find Full Text PDFFASEB J
March 2025
Cancer Center, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China.
Breast cancer (BC) is one of the most common malignant tumors among women, accounting for 24.5% of all cancer cases and leading to 15.5% of cancer-related mortality.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!