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Microwave-assisted synthesis and biological evaluation of dihydropyrimidinone derivatives as anti-inflammatory, antibacterial, and antifungal agents. | LitMetric

Microwave-assisted synthesis and biological evaluation of dihydropyrimidinone derivatives as anti-inflammatory, antibacterial, and antifungal agents.

Int J Med Chem

Laboratory of Heterocycles, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain, Madhya Pradesh 456010, India.

Published: November 2014

A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238236PMC
http://dx.doi.org/10.1155/2013/197612DOI Listing

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