FOXP2, retinoic acid, and language: a promising direction.

Front Cell Neurosci

Catalan Institute for Advanced Studies and Research (ICREA) Barcelona, Spain ; Department of Linguistics, Universitat de Barcelona Barcelona, Spain.

Published: November 2014

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230053PMC
http://dx.doi.org/10.3389/fncel.2014.00387DOI Listing

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Article Synopsis
  • Speech involves complex motor control, coordinated by neural circuits like cortico-striato-thalamic loops, allowing most people to speak effortlessly.
  • FOXP2 is a key gene linked to speech and language disorders, where mutations lead to significant communication impairments, highlighting its role in speech-motor control mechanisms.
  • Recent findings suggest that FOXP2 interacts with retinoic acid (RA) signaling, which impacts brain development and may be crucial for fine motor skills and speech production, providing new avenues for research into the genetics of language readiness.
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