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Social media-based Health Education plus Exercise Program (SHEEP) to improve muscle function among young-old adults with possible sarcopenia in the community: A feasibility study protocol.
PLoS One
January 2025
Faculty of Biology, School of Health Sciences, Medicine & Health, University of Manchester, Manchester, United Kingdom.
Background: Despite the comparatively high prevalence of possible sarcopenia among young-old adults in the community, there is currently no available and effective social media-based intervention to increase the awareness and change the behavior of the target population to prevent sarcopenia. Using co-design methodology, we developed a multicomponent intervention strategy of health education and exercise for sarcopenia prevention utilizing the TikTok platform.
Objectives: The primary purpose of this study is to examine the feasibility and acceptability of the social media-based intervention to enhance muscle function in community-dwelling young-old adults with possible sarcopenia.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Michigan Medical School, Ann Arbor, MI, USA.
Background: The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has been linked to lifespan in non-human species and recently demonstrated to occur in rare instances from one human generation to the next.
Method: Here we investigated numtogenesis dynamics in humans in two ways. First, we quantified Numts in 1,187 post-mortem brain and blood samples from different individuals.
Factors impacting human-perceived visual quality on television displays.
Front Neurosci
December 2024
Munsell Color Science Laboratory, Rochester Institute of Technology, Rochester, NY, United States.
There is a growing interest in understanding the factors that influence a user's perception and preferences for video quality. This study specifically focuses on how various factors, including video content, display settings, viewer characteristics, and the ambient environment, affect the subjective video quality assessment (VQA) of TV displays. To investigate these factors, two psychophysical experiments were conducted, and the results indicate that all four factors have a significant impact on video quality perception in different ways.
View Article and Find Full Text PDFEducation Research: The Neurohumanities in Training: Integrating a Humanities Curriculum Within Neurology Residency Programs.
Neurol Educ
December 2024
From the Department of Neurology (M.R., C.P.), Medical University of South Carolina, Charleston; Department of Neurology (T.G.), Boston Medical Center, MA; Department of Neurology (G.S.P.), University of California San Francisco; Department of Neurology (R.V.A.), University of Colorado Anschutz Medical Campus, Aurora; Department of Neurology (A.F., M.G.), The University of Texas Southwestern Medical Center, Dallas; Department of Neurology (R.A.C.), University of Massachusetts Medical School, Worcester; Mass General Brigham Neurology Residency Program (G.G.), Brigham and Women's Hospital and Massachusetts General Hospital, Boston; and Neurocognitive Division (M.P.H.S.), Tufts Medical Center, Boston.
Background And Objectives: Perhaps stemming from the central role of detailed examinations and a focus on the subjective sphere that grounds their clinical practice, neurologists have frequently opined on experiences traditionally a province of humanities. The increasingly technological focus on medical education and care can be seen to devalue the subjective aspects of medicine. As a counter to this, we report on the existence of neurohumanities curricula within neurology residency training.
View Article and Find Full Text PDFRole of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis.
J Virol
December 2024
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Protein kinase R (PKR) is an interferon-induced antiviral protein activated by autophosphorylation in response to double strand DNA (dsRNA) and other stimuli. Activated PKR causes translation inhibition and apoptosis, and it contributes to proinflammatory responses, cell growth, and differentiation. Mouse adenovirus type 1 (MAV-1) counteracts PKR by causing its degradation via a viral protein, early region 4 open reading frame 6 (E4orf6).
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