The aim of this study was to assess the efficacy of topical application of a liposomal formulation of itraconazole for the treatment of experimental keratitis with endophthalmitis caused by Aspergillus flavus. The liposomes were obtained by the lipid film hydration method followed by sonication. Adult female Wistar rats (weighing 200-220 g) were immunosuppressed by intraperitoneal injection of 150 mg/kg of cyclophosphamide 3 days before infection by exposure to the fungus A. flavus (10(7) spores/ml). Forty-eight hours later, the animals were treated with the liposomal formulation. For comparison, one group of animals (n = 6) was treated with the same drug not encapsulated. At the end of the experiment, the animals were evaluated for clinical signs and number of colony forming units (CFU/g), along with direct microscopic examination. The results indicated that the liposomal formulation of itraconazole has better antifungal activity than the unencapsulated drug in the treatment of fungal keratitis with endophthalmitis caused experimentally by A. flavus in Wistar rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11046-014-9837-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Bioinspired Virus-Like Mechano-Bactericidal Nanomotor for Ocular Multidrug-Resistant Bacterial Infection Treatment.
Adv Mater
January 2025
Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University, Qingdao, 266071, P. R. China.
Multidrug-resistant (MDR) bacteria and their associated biofilms are major causative factors in eye infections, often resulting in blindness and presenting considerable global health challenges. Presently, mechano-bactericidal systems, which combine distinct topological geometries with mechanical forces to physically induce bacterial apoptosis, show promising potential. However, the physical interaction process between current mechano-bactericidal systems and bacteria is generally based on passive diffusion or Brownian motion and lacks the force required for biofilm penetration; thus, featuring low antibacterial efficacy.
View Article and Find Full Text PDFInfectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center.
J Ophthalmic Inflamm Infect
January 2025
School of medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran.
Introduction: Infectious keratitis is a rare but devastating complication following photorefractive keratectomy (PRK) that may lead to visual impairment. This study assessed the clinical features, treatment strategies, and outcomes of post-PRK infectious keratitis.
Methods: This retrospective study was conducted on patients with post-PRK infectious keratitis presenting to Khalili Hospital, Shiraz, Iran, from June 2011 to March 2024.
Bleb-related endophthalmitis during an epidemic of viral keratoconjunctivitis.
BMJ Case Rep
December 2024
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Article Synopsis
- North India experiences an annual outbreak of viral conjunctivitis during the monsoon season, impacting a large number of people, most of whom recover without treatment.
- Patients with a history of trabeculectomy (eye surgery for glaucoma) are at increased risk as conjunctivitis can lead to serious complications like blebitis and bacterial/fungal infections.
- It's crucial to educate these patients about the conjunctivitis outbreak and the warning signs that require immediate medical attention to prevent complications.
State-of-the-Art Review: Ocular Infections.
Clin Infect Dis
November 2024
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review challenges in common and uncommon eye infections to promote better understanding of these infections and prioritize areas for further research.
View Article and Find Full Text PDFPovidone iodine-infused pars plana vitrectomy for severe fungal endophthalmitis.
Am J Ophthalmol Case Rep
December 2024
Department of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA.
Purpose: Arthrographis kalrae is an opportunistic fungus that can cause a severe and atypical endophthalmitis. In limited studies, low-dose povidone iodine has been shown to be effective in treating fulminant bacterial endophthalmitis. In this case report, we describe the successful treatment of recalcitrant keratitis-associated endophthalmitis with intraocular povidone iodine during pars plana vitrectomy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!