AI Article Synopsis
- * The study identifies nidogens (or entactins) as key components that facilitate TeNT binding at the NMJ.
- * Inhibiting the interaction between TeNT and nidogens can prevent the toxin from binding to neurons, offering a potential pathway for new treatments to combat tetanus.
Article Abstract
Tetanus neurotoxin (TeNT) is among the most poisonous substances on Earth and a major cause of neonatal death in nonvaccinated areas. TeNT targets the neuromuscular junction (NMJ) with high affinity, yet the nature of the TeNT receptor complex remains unknown. Here, we show that the presence of nidogens (also known as entactins) at the NMJ is the main determinant for TeNT binding. Inhibition of the TeNT-nidogen interaction by using small nidogen-derived peptides or genetic ablation of nidogens prevented the binding of TeNT to neurons and protected mice from TeNT-induced spastic paralysis. Our findings demonstrate the direct involvement of an extracellular matrix protein as a receptor for TeNT at the NMJ, paving the way for the development of therapeutics for the prevention of tetanus by targeting this protein-protein interaction.
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| http://dx.doi.org/10.1126/science.1258138 | DOI Listing |
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