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Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. | LitMetric

AI Article Synopsis

  • * TLR5 on dendritic cells enhances the presentation of flagellin peptides, boosting flagellin-specific T-cell responses both in lab settings and in living organisms.
  • * Research reveals that spleen tyrosine kinase and CARD9, an alternative TLR-signaling pathway, are key in modulating the strength of flagellin-specific CD4(+) T-cell responses, highlighting a previously overlooked signaling route.

Article Abstract

Toll-like receptors (TLRs) can recognize microbial patterns and utilize adaptor molecules, such as-MyD88 or (TRIF TIR-domain-containing adapter-inducing interferon-β), to initiate downstream signaling that ultimately affects the initiation of adaptive immunity. In addition to this inflammatory role, TLR5 expression on dendritic cells can favor antigen presentation of flagellin peptides and thus increase the sensitivity of flagellin-specific T-cell responses in vitro and in vivo. Here, we examined the role of alternative signaling pathways that might regulate flagellin antigen presentation in addition to MyD88. These studies suggest a requirement for spleen tyrosine kinase, a noncanonical TLR-signaling adaptor molecule, and its downstream molecule CARD9 in regulating the sensitivity of flagellin-specific CD4(+) T-cell responses in vitro and in vivo. Thus, a previously unappreciated signaling pathway plays an important role in regulating the dominance of flagellin-specific T-cell responses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324162PMC
http://dx.doi.org/10.1002/eji.201444744DOI Listing

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