Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection.
Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression.
Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275942 | PMC |
| http://dx.doi.org/10.1186/s12977-014-0095-7 | DOI Listing |
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