AI Article Synopsis
- Human cancers rely on vascularization for growth, invasion, and metastasis, with endothelial progenitor cells (EPCs) playing a key role in this process.
- Recent studies show an increase in circulating EPCs (CEPCs) in cancer patients, linking their levels to clinical outcomes and making them a potential biomarker for diagnosis and prognosis.
- The review emphasizes the need for improved detection methods and more extensive clinical research to better understand the role and significance of CEPCs in cancer treatment and outcomes.
Article Abstract
Human cancers are endowed with sustained vascularization capability, and their growth, invasion, and metastasis are vascularization dependent. Recently, accumulated body of evidence suggests that endothelial progenitor cells (EPCs) can support vasculogenesis and induce angiogenesis through paracrine mechanisms. In addition, numerous clinical studies have revealed the increase in the number of EPCs in the peripheral blood of cancer patients and demonstrated the correlation of circulating EPCs (CEPCs) with the clinical outcomes. This review highlights current enrichment procedures and methods for the detection of CEPCs and different biomarkers to identify CEPCs as well as the functions of EPCs in tumor vascularization. Furthermore, we systematically review available studies on the clinical relevance of CEPCs in cancer patients to explore the potential diagnostic and prognostic values of CEPCs. Although several contrasting results exist, CEPCs can conceivably serve as a promising biomarker for the early diagnosis, prognosis prediction, and treatment response indication in the future. Additionally, further well-designed clinical studies with larger sample size and unique, specific enumeration procedures are warranted to achieve further insight into the clinical implications of CEPCs.
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| http://dx.doi.org/10.1007/s12032-014-0332-x | DOI Listing |
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