Background: Delirium is a complex neuropsychiatric syndrome that is common among elderly inpatients. It has been associated with increased mortality, longer hospital stays, cognitive and functional decline and increased institutionalisation rates. Multicomponent interventions, a series of non-pharmacological strategies frequently handled by nursing staff, might be useful for prevention.
Objectives: To assess the efficacy of multicomponent interventions in preventing incident delirium in the elderly.
Methods: A systematic review of randomised trials was undertaken. Two independent reviewers performed iterative literature searches in seven databases without language restrictions. Grey literature repositories were considered as well. The quality of included trials was assessed by using the criteria established by the Cochrane Collaboration. When possible, data were synthesised into a meta-analysis. Heterogeneity was assessed using the χ2 and I2 tests.
Findings: A total of 21,788 citations were screened, and seven studies of diverse quality were included in the review, comprising 1,691 participants. Multicomponent interventions significantly reduced incident delirium (relative risk [RR] 0.73, 95% confidence interval [CI] 0.63-0.85, P<0.001) and accidental falls during the hospitalisation (RR 0.39, 95% CI 0.21, 0.72, P=0.003), without evidence of differential effectiveness according to ward type or dementia rates. Non-significant reductions in delirium duration, hospital stay and mortality were found as well.
Interpretation: Multicomponent interventions are effective in preventing incident delirium among elderly inpatients. Effects seemed to be stable among different settings. Due to the limited amount of data, potential benefits in survival need to be confirmed in further studies. Future research should be aimed at contrasting different multicomponent programmes to select the most useful interventions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ageing/afu173 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Probing Surface Reactions on Multicomponent Glass Using Reflection-Absorption Infrared Spectroscopy.
Langmuir
January 2025
Department of Chemical Engineering and Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
The chemical reactivity of glass surfaces is often studied with elemental analysis techniques, and although such characterization methods provide insights on compositional changes from exposure to specific chemical conditions, molecule-specific chemical reactions are not determined unambiguously. This study demonstrates the use of reflection-absorption infrared spectroscopy (RAIRS) to detect molecular species on alkali-free boroaluminosilicate and alkali aluminosilicate glasses, using acetic acid vapor as a model reactant to probe reaction sites at the surface with or without pretreatment by aqueous solutions of varied pH. With the assistance of the theoretical calculation of spectral changes based on refractive indices of bulk materials, it was possible to identify the molecular species being removed and produced at the glass surface.
View Article and Find Full Text PDFA comprehensive evaluation of the quality of Bu Shen Jian Gu oral liquid based on multi-indicator component quantification and chemical pattern recognition.
Anal Methods
January 2025
Guangxi University of Chinese Medicine, Key Laboratory of Extraction, Purification and Quality Analysis of TCM in Guangxi University, Nanning 530200, P. R. China.
Bu Shen Jian Gu Oral Liquid (BSJG) is a hospital formulation commonly utilized in the treatment of fractures, joint dislocations, and rheumatoid arthritis. However, there has been no effective and straightforward method to comprehensively assess the quality of BSJG. In this experiment, a fingerprint of various batches of BSJG was established using high-performance liquid chromatography (HPLC).
View Article and Find Full Text PDFGeneralizable, sequence-invariant deep learning image reconstruction for subspace-constrained quantitative MRI.
Magn Reson Med
January 2025
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Purpose: To develop a deep subspace learning network that can function across different pulse sequences.
Methods: A contrast-invariant component-by-component (CBC) network structure was developed and compared against previously reported spatiotemporal multicomponent (MC) structure for reconstructing MR Multitasking images. A total of 130, 167, and 16 subjects were imaged using T, T-T, and T-T- -fat fraction (FF) mapping sequences, respectively.
Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis.
J Ovarian Res
January 2025
LongHua Hospital Shanghai University of Traditional Chinese Medicine, No.725 Wanping South Road, Xuhui District, Shanghai, 200032, China.
Objective: To systematically evaluate the effectiveness of non-pharmacological interventions (NPIs), including electroacupuncture, exercise, diet, and lifestyle changes, in reducing androgen levels in women with polycystic ovary syndrome (PCOS) through a systematic review and network meta-analysis.
Methods: Comprehensive searches were conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang up to June 2024. Randomized controlled trials (RCTs) comparing NPIs with other NPIs or placebo treatments in adult women with PCOS were included.
Addressing unmet mental health needs of older adults in Turbo, Colombia: a multi-component psychosocial intervention feasibility study.
Int J Equity Health
January 2025
National School of Public Health, University of Antioquia, Medellín, Colombia.
Background: Older adults have lived through extreme and stressful live events in Colombia, including during the armed conflict. Without adequate mental health resources in place, the aim of this study was to feasibility test a co-produced community-integrated intervention for older adults to improve their mental health and well-being in Turbo, Colombia.
Methods: Based on a systematic review and meta-analysis of community-based mental health interventions for older adults in LMICs, qualitative interviews with older adults and local stakeholders, as well as a mental health needs assessment survey of the local older adult population in Turbo, Colombia, we consulted older adults in the region to co-produce a community-based intervention.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!