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http://dx.doi.org/10.1001/jama.2014.14334 | DOI Listing |
Antibiotics (Basel)
December 2024
Division of Pharmaceutical and Medical Law, Department of Social Medicine, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str. 15, 80-210 Gdansk, Poland.
The increasing consumption of pharmaceuticals, including antibiotics, and their improper disposal have resulted in both pharmaceuticals and their metabolites being released into the environment, where they pose a risk to both ecosystems and human health. One of the most serious threats to public health associated with the presence of antibiotics in the environment is antimicrobial resistance (AMR). In order to combat AMR, the legal aspect of water protection becomes a critical area of action.
View Article and Find Full Text PDFMetabolites
January 2025
School of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China.
: Sarcopenia, characterized by the progressive loss of muscle mass and strength, is linked to physical disability, metabolic dysfunction, and an increased risk of mortality. Exercise therapy is currently acknowledged as a viable approach for addressing sarcopenia. Nevertheless, the molecular mechanisms behind exercise training or physical activity remain poorly understood.
View Article and Find Full Text PDFCell Metab
January 2025
Leibniz Institute for Analytical Sciences, ISAS e.V., Dortmund, Germany; School of Molecular Biosciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address:
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing lifespan extension and enhanced mobility in Caenorhabditis elegans, accompanied by improved stress resistance and reduced age-associated biomarkers. In aged rats, ET administration enhances exercise endurance, muscle mass, and vascularization, concomitant with higher NAD levels in muscle.
View Article and Find Full Text PDFCell Commun Signal
January 2025
Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
Cardiolipin, a unique phospholipid predominantly present in the inner mitochondrial membrane, is critical for maintaining mitochondrial integrity and function. Its dimeric structure and role in supporting mitochondrial dynamics, energy production, and mitophagy make it indispensable for skeletal muscle health. This review provides a comprehensive overview of cardiolipin biosynthesis, remodeling processes, and essential functions within mitochondria.
View Article and Find Full Text PDFSci Rep
January 2025
Jiangsu Transportation Institute Group (JSTI), Nanjing, China.
During multi-agent combat simulation exercises, accurately assessing the quality of collected combat data is a critical step. Addressing the current issue of low accuracy in combat data quality evaluation, which fails to effectively support simulation exercises, this paper proposes a Double-Weighted FAHP optimized by CVF (comparative value function) method for assessing combat data quality. First, a three-tiered evaluation framework for combat data quality indicators is established, with threshold values determined for each indicator.
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