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Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks.
Transl Psychiatry
February 2024
Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000, Grenoble, France.
Impulse control disorders (ICDs), a wide spectrum of maladaptive behaviors which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested to be triggered or aggravated by treatments with dopamine D receptor agonists, such as pramipexole (PPX). Despite evidence showing that impulsivity is associated with functional alterations in corticostriatal networks, the neural basis of the exacerbation of impulsivity by PPX has not been elucidated. Here we used a hotspot analysis to assess the functional recruitment of several corticostriatal structures by PPX in male rats identified as highly (HI), moderately impulsive (MI) or with low levels of impulsivity (LI) in the 5-choice serial reaction time task (5-CSRTT).
View Article and Find Full Text PDFSexuality in the lives of people with intellectual disabilities: A meta-ethnographic synthesis of qualitative studies.
Res Dev Disabil
April 2018
Department of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. Electronic address:
Background: The normalisation movement calls for more recognition of the sexual rights of people with intellectual disabilities to challenge classically paradoxical cultural beliefs: 'hypersexual' versus 'asexual'.
Aims: This meta-ethnographic qualitative synthesis aimed to explore the voices of people with intellectual disabilities in regards to their experiences and perceptions of sexuality using a Coordinated Management of Meaning framework to derive new conceptual understandings of how their sexuality exists within multiple contexts.
Methods And Procedures: A systematic literature search and quality assessment yielded 16 studies that met the inclusion criteria and were synthesised following the method of meta-ethnography.
A case of Klinefelter syndrome with hypersexual desire.
Endocrinol Diabetes Metab Case Rep
August 2017
Department of Endocrinology, Canberra Hospital, Canberra, ACTAustralia.
Unlabelled: Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders.
View Article and Find Full Text PDFParadoxical hypersexuality in depression.
Aust N Z J Psychiatry
March 2015
Director, The Monash Alfred Psychiatry Research Centre, Melbourne, Australia.
Effects of sleep deprivation during pregnancy on the reproductive capability of the offspring.
Fertil Steril
December 2013
Departamento de Psicobiologia-Universidade Federal de São Paulo, São Paulo.
Objective: To investigate the effects of sleep deprivation during pregnancy on the reproductive capability of the offspring.
Design: Using a sleep loss model or control home-cage group (male and females rats) to evaluate sexual behavior and hormonal profile in males and females F1 offspring.
Setting: Laboratory.
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