[Effect of a natriuretic factor of hepatic origin on the indices of water-salt metabolism and blood circulation].

The influence of natriuretic factor inhibiting the Na--K--ATPase, on the volume-regulating function of kidneys and the hemodynamics was studied in dogs. A single administration of natriuretic factor in a dose increasing the renal excretion of water, sodium and osmotically active substances, affected the hemodynamics. The changes of both the central hemodynamics and of the renal blood circulation were of a shorter duration compared with the changes in renal functions. The activation of water and electrolyte-excreting activity of the kidneys seems to be due to a reduced tubular reabsorption but not to the glomerular filtration.