Background: Transplant glomerulopathy (TG) may occur early after transplantation, and electron microscopy may contribute to diagnose it.
Methods: We analyzed kidney transplant biopsies from September 2009 to September 2012 to identify the presence of histologic changes associated with TG.
Results: Forty-eight biopsies from 65 patients, met the study criteria and were evaluated. The average evolution time of transplantation was 13.6 months. Sixty percent of patients received deceased-donor renal transplants, and biopsies were performed per protocol in most cases. Electron microscopy diagnosed the presence of changes associated with TG in 23% of patients. Light microscopy was not useful in the diagnosis of such graft pathology. The average transplantation time was significantly higher in patients with TG compared to patients without TG (20.6 mo vs 11.5 mo; P = .03). Light microscopy diagnosed mild interstitial fibrosis/tubular atrophy in 27 patients, of which 6 had early changes of TG according to the analysis by electron microscopy.
Conclusions: Electron microscopy improves accurate diagnosis of TG, in patients both with and without graft dysfunction. It also allows diagnosis of early TG and thereby identification of patients who may have lower graft survival.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.transproceed.2014.07.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Revealing mitochondrial architecture and functions with single molecule localization microscopy.
Biol Cell
January 2025
CNRS, Univ Rennes, IGDR [(Institut de Génétique et Développement de Rennes)]-UMR 6290, Rennes, France.
Understanding the spatiotemporal organization of components within living systems requires the highest resolution possible. Microscopy approaches that allow for a resolution below 250 nm include electron and super-resolution microscopy (SRM). The latter combines advanced imaging techniques and the optimization of image processing methods.
View Article and Find Full Text PDFFlotillins in membrane trafficking and physiopathology.
Biol Cell
January 2025
CRBM (Centre de Recherche en Biologie cellulaire de Montpellier), BIOLuM, University of Montpellier, CNRS UMR 5237, Montpellier, France.
Flotillin 1 and 2 are highly conserved and homologous members of the stomatin, prohibitin, flotillin, HflK/C (SPFH) family. These ubiquitous proteins assemble into hetero-oligomers at the cytoplasmic membrane in sphingolipid-enriched domains. Flotillins play crucial roles in various cellular processes, likely by concentrating sphingosine.
View Article and Find Full Text PDFPerformance of Extracellular Vesicles From () for Serological Diagnosis of Human and Canine Visceral Leishmaniasis.
J Parasitol Res
January 2025
Parasitology and Mycology Center, Adolfo Lutz Institute, Sao Paulo, Brazil.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
View Article and Find Full Text PDFHybrid additive manufacturing for Zn-Mg casting for biomedical application.
In Vitro Model
December 2024
Department of Industrial and Manufacturing Engineering, Pennsylvania State University, State College, University Park, PA USA.
Zinc (Zn) and its alloys have been the focus of recent materials and manufacturing research for orthopaedic implants due to their favorable characteristics including desirable mechanical strength, biodegradability, and biocompatibility. In this research, a novel process involving additive manufacturing (AM) augmented casting was employed to fabricate zinc-magnesium (Zn-0.8 Mg) artifacts with surface lattices composed of triply periodic minimal surfaces (TPMS), specifically gyroid.
View Article and Find Full Text PDFReactivity of Wet scCO toward Reservoir and Caprock Formations under Elevated Pressure and Temperature Conditions: Implications for CCS and CO-Based Geothermal Energy Extraction.
Energy Fuels
January 2025
Geothermal Energy and Geofluids Group, Institute of Geophysics, Department of Earth and Planetary Sciences, ETH Zurich, Zurich 8092, Switzerland.
Carbon capture and storage (CCS) and CO-based geothermal energy are promising technologies for reducing CO emissions and mitigating climate change. Safe implementation of these technologies requires an understanding of how CO interacts with fluids and rocks at depth, particularly under elevated pressure and temperature. While CO-bearing aqueous solutions in geological reservoirs have been extensively studied, the chemical behavior of water-bearing supercritical CO remains largely overlooked by academics and practitioners alike.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!