Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746475 | PMC |
| http://dx.doi.org/10.1002/smll.201402017 | DOI Listing |
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