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| http://dx.doi.org/10.1111/idj.12152 | DOI Listing |
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Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Alzheimer's Disease (AD) is a common form of dementia among the elderly with a large percentage of estimated heritability. Conventional polygenic risk analysis only accounts for the linearly combined genomic effects of single nucleotide polymorphisms (SNPs). On the other hand, a deep-learning-based approach is able to uncover nonlinearly associated effects from data with high-dimensional features such as genomics.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Tennessee, Knoxville, TN, USA.
Background: The prevalence of Alzheimer's disease and related dementias (ADRD) presents a growing public health challenge. This study introduces an innovative approach to dementia care through the development of AI agents that simulate the interactions between people living with dementia (PLWD) and their caregivers during activities of daily living (ADLs).
Method: The study employs ChatGPT (GPT4) large language models to create AI agents representing both PLWD and interventionists.
Organizational readiness for implementation: a qualitative assessment to explain survey responses.
BMC Health Serv Res
January 2025
Center for Health Promotion and Prevention Research, School of Public Health, UT Health Houston, Houston, TX, USA.
Background: One factor considered essential to successful implementation is organizational readiness. The purpose of this study was to explore ways to improve the measurement of organizational readiness, and in particular to refine a preliminary measure based on the Readiness = Motivation x innovation Specific Capacity x General Capacity (R = MC2) heuristic. We assessed the experiences of staff in Federally Qualified Health Centers (FQHC) implementing evidence-based interventions (EBIs) designed to increase colorectal cancer screening (CRCS) who previously completed the survey and aimed to understand their perspectives on why our data were positively skewed.
View Article and Find Full Text PDFStrong, ductile, and hierarchical hetero-lamellar-structured alloys through microstructural inheritance and refinement.
Proc Natl Acad Sci U S A
January 2025
Department of Materials Science and Engineering, Hong Kong Institute for Advanced Study, City University of Hong Kong, Hong Kong, China.
The strength-ductility trade-off exists ubiquitously, especially in brittle intermetallic-containing multiple principal element alloys (MPEAs), where the intermetallic phases often induce premature failure leading to severe ductility reduction. Hierarchical heterogeneities represent a promising microstructural solution to achieve simultaneous strength-ductility enhancement. However, it remains fundamentally challenging to tailor hierarchical heterostructures using conventional methods, which often rely on costly and time-consuming processing.
View Article and Find Full Text PDFBarriers to breast cancer care and recommendations for improving services: findings from a UK qualitative study with an Asian Women's Cancer Support Group.
Ethn Health
January 2025
Berkshire Healthcare NHS Foundation Trust, Equality, Diversity and Inclusion, Reading, UK.
Objectives: Breast cancer is the most common cancer in the UK, accounting for 15% of all new cases in women. Evidence still points to disparities in outcomes linked to ethnicity and screening uptake is overall lower in South Asians than the White population. We investigated the experiences and perceptions of Gujarati Hindu community members on their 'cancer journeys'.
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