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Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial.
JAMA
March 2023
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Importance: Olamkicept, a soluble gp130-Fc-fusion-protein, selectively inhibits interleukin 6 (IL-6) trans-signaling by binding the soluble IL-6 receptor/IL-6 complex. It has anti-inflammatory activities in inflammatory murine models without immune suppression.
Objective: To assess the effect of olamkicept as induction therapy in patients with active ulcerative colitis.
'Do-it-yourself' dental treatment: a case report.
Dent Update
October 2002
Maxillofacial Unit, Morriston Hospital, Swansea.
The use of topical desensitizing agents and the placement of superficial restorations at cervical margins are part of a conventional treatment plan for hypersensitive teeth. This case report describes a dental-phobic patient who employed a rather peculiar 'do-it-yourself' approach to alleviate the problems of hypersensitivity, by covering her teeth with a mixture of candle wax and 'household' glue.
View Article and Find Full Text PDFHost-parasite interactions in Staphylococcus aureus keratitis.
DNA Cell Biol
August 2002
Department of Biology, Oklahoma Baptist University, Shawnee, Oklahoma 73190, USA.
Ulcerative keratitis is among the leading ocular bacterial infections, and Streptococcus aureus accounts for approximately 25% of cases in some surveys. Although S. aureus expresses numerous virulence factors, many of which are under the control of staphylococcal global regulatory genes, their pathophysiologic roles in keratitis are largely unknown.
View Article and Find Full Text PDFGastric acidity was evaluated, using the histamine test (Key's test), measurement of nocturnal gastric secretion and gastric pH-metry, in 174 patients with gastric ulcers. Acidity proved to be lowered in 25% of gastric ulcers patients, normal in 30% and increased in nearly half of the patients. Intragastric proteolysis was studied in 48 individuals, including 27 patients with peptic ulcers and 21 normal controls.
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