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The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank.
Br J Anaesth
January 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Department of Rheumatology, Mayo Clinic, Jacksonville, FL, USA.
Background: Chronic primary pain describes conditions where pain is the principal problem rather than a consequence of another disease. Primary pain is thought to be primarily owing to nociplastic pain (i.e.
View Article and Find Full Text PDFHealth-related quality of life across menopausal stages among middle-aged Korean women.
Menopause
January 2025
National Institute of Health, Cheongju, Republic of Korea.
Objectives: We examined the health-related quality of life (HRQoL) during menopause transition (MT) among middle-aged Korean women.
Methods: This cross-sectional study comprised 2,290 middle-aged women who completed web-based questionnaires between 2020 and 2022. Based on self-reported menstrual cycle patterns, menopause status was classified as premenopausal, early or late transition, or postmenopausal.
Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled Trial.
Cell Transplant
January 2025
Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neuropathic pain is a debilitating complication following spinal cord injury (SCI). Currently, effective treatments for SCI-induced neuropathic pain are highly lacking. This clinical trial aimed to investigate the efficacy of combined intrathecal injection of Schwann cells (SCs) and bone marrow-derived mesenchymal stem cells (BMSCs) in improving SCI-induced neuropathic pain.
View Article and Find Full Text PDFRelationships between orofacial pain and sleep: Analysis of UK biobank and genome-wide association studies data.
J Dent Sci
January 2025
Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
Background/purpose: Orofacial pain is common in dental practices. This study aimed to explore relationships between orofacial pain and sleep using the UK Biobank dataset and, based on epidemiological associations, to investigate the causal association using genome-wide association studies data.
Materials And Methods: First, a cross-sectional study was conducted with 196,490 participants from UK Biobank.
A comparative analysis of older patients with chewing difficulties due to temporomandibular disorders and tooth loss.
J Dent Sci
January 2025
Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.
Background/purpose: Chewing difficulty can contribute to psychological stress, which reduces the quality of life for older adults. The purpose of this study was to investigate and analyze the severity of masticatory discomfort, stress response, and sleep disturbance in older patients experiencing masticatory discomfort due to tooth loss or temporomandibular disorders (TMD), to find the further treatment direction for these patients.
Materials And Methods: A total of 392 patients aged 50 years and older with mastication difficulties were analyzed.
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